Synthesis and evaluation of nitroheterocyclic aromatic adamantane amides with trypanocidal activity. Part II

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Abstract:

New nitroheterocyclic adamantane amides display promising trypanocidal activity. The spacer length between the adamantylphenyl backbone and the nitroheterocyclic ring plays a crucial role in potency.

SEEK ID: https://fairdomhub.org/publications/814

DOI: 10.1039/d5md00527b

Projects: WG1 - Compound libraries coordination and integration of compound design, WG2 - Integration of early phase studies and low environmental impact ac..., WG3 - Coordination of in vitro-to-in vivo translation of OneHealth leads..., WG4 - Integration of R&D process-environmental studies and translation i...

Publication type: Journal Article

Journal: RSC Medicinal Chemistry

Book Title: RSC Medicinal Chemistry

Publisher: Royal Society of Chemistry (RSC)

Citation: RSC Med. Chem. 17(1):590-605.

Date Published: 2026

Registered Mode: by DOI

Authors: Angeliki-Sofia Foscolos, Richard L. Atherton, Maria Billia, Markos-Orestis Georgiadis, Nuno Santarém, Anabela Cordeiro da Silva, Martin C. Taylor, John M. Kelly, Theodora Calogeropoulou, Andrew Tsotinis, Thomas Mavromoustakos, Ioannis P. Papanastasiou

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Ulrike Wittig

Citation

Foscolos, A.-S., Atherton, R. L., Billia, M., Georgiadis, M.-O., Santarém, N., da Silva, A. C., Taylor, M. C., Kelly, J. M., Calogeropoulou, T., Tsotinis, A., Mavromoustakos, T., & Papanastasiou, I. P. (2026). Synthesis and evaluation of nitroheterocyclic aromatic adamantane amides with trypanocidal activity. Part II. In RSC Medicinal Chemistry (Vol. 17, Issue 1, pp. 590–605). Royal Society of Chemistry (RSC). https://doi.org/10.1039/d5md00527b

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Created: 14th Jul 2026 at 08:50

Synthesis and evaluation of nitroheterocyclic aromatic adamantane amides with trypanocidal activity. Part II

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