Oxyprenyl–chalcones as antibacterial hits: design of experiments-optimized synthesis, antibacterial evaluation, early drug-like profiling and biodegradability prediction

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Abstract:

The escalating threat of antimicrobial resistance (AMR) compels the development of novel antibiotics with broad spectrum activity and environmentally responsible degradation profiles.

SEEK ID: https://fairdomhub.org/publications/798

DOI: 10.1039/d5md00839e

Projects: WG1 - Compound libraries coordination and integration of compound design, WG2 - Integration of early phase studies and low environmental impact ac..., WG3 - Coordination of in vitro-to-in vivo translation of OneHealth leads..., WG4 - Integration of R&D process-environmental studies and translation i...

Publication type: Journal Article

Journal: RSC Medicinal Chemistry

Book Title: RSC Medicinal Chemistry

Publisher: Royal Society of Chemistry (RSC)

Citation: RSC Med. Chem. 17(3):1573-1585.

Date Published: 2026

Registered Mode: by DOI

Authors: Ludovica Marotta, Francesca Maria Pia Rita Giammarino, Brondon Brandly Senenou Tambou, Valeria Tudino, Stefania Butini, Lorenza Broccardo, Sacha Michèle Idriss Cancade, Jean-Denis Docquier, Federica Perego, Nicoletta Basilico, Lorenzo Raffellini, Sheraz Gul, Gabriele Carullo, Sandra Gemma, Giuseppe Campiani

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Citation
Marotta, L., Giammarino, F. M. P. R., Senenou Tambou, B. B., Tudino, V., Butini, S., Broccardo, L., Cancade, S. M. I., Docquier, J.-D., Perego, F., Basilico, N., Raffellini, L., Gul, S., Carullo, G., Gemma, S., & Campiani, G. (2026). Oxyprenyl–chalcones as antibacterial hits: design of experiments-optimized synthesis, antibacterial evaluation, early drug-like profiling and biodegradability prediction. In RSC Medicinal Chemistry (Vol. 17, Issue 3, pp. 1573–1585). Royal Society of Chemistry (RSC). https://doi.org/10.1039/d5md00839e
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Created: 14th Jul 2026 at 08:35

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