WP 2: Antimalarial drug encapsulation

LEADER: StU (prof. B. Klumperman)

PARTNERS: StU & SU

OBJECTIVES:

• Optimization of antimalarial drug encapsulation for fast release.

• Development of transmission blocking drug encapsulation for slow release.

DELIVERABLES:

07.2022 D 2.1

Protocol for the preparation of solid lipid nanoparticle loaded with antimalarial drugs. (SU)

07.2022 D 2.3

Synthesis of amphiphilic block copolymers poly(N-vinylpyrrolidone-block-(lactic acid-co-glycolic acid)) (PVP-b-PLGA) (StU)

10.2022 D 2.5

Synthesis of allyl-functional monomer and of allyl-functional block copolymers (StU)

07.2023 M 2.1

Fast release profile of the antimalarial drugs encapsulated in the solid lipid nanoparticles.

07.2023 M 2.2

Slow release profile of transmission blocking drugs via biodegradation of PLGA particles.

10.2023 D 2.2

Drug loading and release study of antimalarial drugs from solid lipid nanoparticles (SU)

10.2023 D 2.4

Self-assembly, drug loading and release study of the copolymer particles (StU)

01.2024 D 2.6

Drug loading and release from allyl-functional systems (StU)