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Projects: IMOMESIC
Institutions: Charité University Medicine Berlin
Projects: MESI-STRAT
Institutions: Charité University Medicine Berlin
Projects: IMOMESIC
Institutions: Charité University Medicine Berlin
Projects: Kinetics on the move - Workshop 2016, Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), FAIRDOM user meeting, COMBINE Multicellular Modelling, FAIRDOM & LiSyM & de.NBI Data Structuring Training
Institutions: Charité University Medicine Berlin, Humboldt-Universität zu Berlin, Humboldt University Berlin

Roles: Project Coordinator
Expertise: Computational modelling, Metabolic Models, Kinetic modelling, Liver, Metabolic Networks, Computational Biology
Tools: SBML, SED-ML, ODE, roadrunner, tellurium, Cytoscape, jupyter notebooks
We are investigating liver metabolism and function with the help of computational models and methods.
Read more about the LiSyM junior group at: www.livermetabolism.com
Junior Group Leader
Dr. Matthias König
Institute for Theoretical Biology
Humboldt-University Berlin
Invalidenstraße 43, 10117 Berlin, Germany
phone +49 30 2093-8450
konigmatt@googlemail.com
The liver is the central metabolic organ of our body playing a crucial role in the clearance of drugs, xenobiotics and numerous metabolites
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Projects: MESI-STRAT
Institutions: Charité University Medicine Berlin
Projects: IMOMESIC
Institutions: Charité University Medicine Berlin
Projects: MESI-STRAT
Institutions: Charité University Medicine Berlin
MESI-STRAT: Systems Medicine of Metabolic-Signaling Networks -A New Concept for Breast Cancer Patient Stratification.
Breast cancer is a complex disease with high prevalence in the European Union and world-wide. 75%-80 of the patients have estrogen receptor-positive (ER)-positive tumors and are treated with endocrine therapies. Endocrine therapies, which block ER-driven tumor growth, show high efficacy. Yet, a significant proportion of the patients will eventually relapse with metastatic breast
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Programme: This Project is not associated with a Programme
Public web page: http://www.mesi-strat.eu
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
We will contribute to the LiSyM Research Network an open source, freely available and reproducible multiscale model of the human liver from single cell metabolism to whole liver function. The model will be available in existing standards of systems biology, provide standardized interfaces for data integration and be fully annotated to available biological, medical and computational ontologies. All data, models and source code will be shared within the LiSyM Research Network and made available to
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Programme: LiSyM - Systems Medicine of the Liver
Public web page: https://livermetabolism.com
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
The COLOSYS project aims to develop a deeper understanding of colon cancer networks and convert them into computer models with which it will be better to predict response to treatment. The combination of computational, experimental and clinical testing will provide understanding of drug resistance mechanisms, and allow personalised treatment of colon cancer.
Programme: Druglogics
Public web page: http://www.colosys.org/
Organisms: Homo sapiens
The workshop focuses on the publication, curation, retrieval, and usage of kinetic data from the reaction kinetics database SABIO-RK and on the use of data in modeling. There will be experience reports from scientists who successfully used experimental data to formulate or verify biological hypotheses with the computer, and you will experience how experimental data can be used with computational models.
Programme: de.NBI Systems Biology Service Center (de.NBI-SysBio)
Public web page: http://www.h-its.org/event/kinetics-on-the-move/
tba.
Programme: Druglogics
Public web page: Not specified
Organisms: Homo sapiens
IMOMESIC - Integrating Modelling of Metabolism and Signalling towards an Application in Liver Cancer
One of the most challenging questions in cancer research is currently the interconnection of metabolism and signalling. An understanding of mechanisms that facilitate the physiological shift towards a proliferative metabolism in cancer cells is considered a major upcoming topic in oncology and is a key activity for future drug development. Due to the complexity of interrelations, a systems biology
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Programme: ERASysAPP
Public web page: Not specified
Organisms: Homo sapiens