Matthias König

About Matthias König:

We are investigating liver metabolism and function with the help of computational models and methods. Read more about the LiSyM junior group at:

Junior Group Leader Dr. Matthias König

Institute for Theoretical Biology Humboldt-University Berlin Invalidenstraße 43, 10117 Berlin, Germany phone +49 30 2093-8450

The liver is the central metabolic organ of our body playing a crucial role in the clearance of drugs, xenobiotics and numerous metabolites from the bloodstream. The quantification of these liver functions is essential to assess the status of the liver, obtain information about the degree of impairment, to evaluate treatment response or to select transplant recipients.

Within the Systems Medicine of the Liver (LiSyM) consortium we establish a standardized multiscale model framework of the human liver readily adaptable to various quantitative liver function tests currently used in the clinics. The resulting models will be personalized with individual imaging data from CT and PET in combination with anthropomorphic information like gender, age, body weight and height and used for the evaluation of quantitative liver function tests in a personalized context.

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