PKDB Caffeine Study

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Pharmacokinetics data set for caffeine

SEEK ID: https://fairdomhub.org/studies/631

Investigation: MM-PLF: Multiscale modeling for personalized liver function

Projects: Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

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Creators and Submitter

Creator

Matthias König

Submitter

Matthias König

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Views: 1186

Created: 19th Jul 2019 at 13:54

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Programmes (1)
Projects (1)
Investigations (1)
Assays (14)
Data files (28)

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Matthias König

Projects: Kinetics on the move - Workshop 2016, Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), FAIRDOM user meeting, COMBINE Multicellular Modelling, FAIRDOM & LiSyM & de.NBI Data Structuring Training

Institutions: Charité University Medicine Berlin, Humboldt-Universität zu Berlin, Humboldt University Berlin

https://orcid.org/0000-0003-1725-179X

Expertise: Computational modelling, Metabolic Models, Kinetic modelling, Liver, Metabolic Networks, Computational Biology, PBPK modeling, Physiological-based pharmacokinetics model

Tools: SBML, SED-ML, ODE, roadrunner, tellurium, Cytoscape, jupyter notebooks

We are investigating liver metabolism and function with the help of computational models and methods.

Group Leader Dr. Matthias König

Institute for Theoretical Biology Humboldt-University Berlin Philippstraße 13, 10115 Berlin, Germany phone +49 30 2093-98435 koenigmx@hu-berlin.de https://www.livermetabolism.com

The König group works on computational modeling, data science, data management, bioinformatics methods and machine learning on ...

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LiSyM - Systems Medicine of the Liver

LiSyM (Liver Systems Medicine) represents a research network of German centers and institutions, brought together by a 20 Million Euro funding program of the German Government, in which mathematicians, modelers, pharmacologists, molecular biologists and clinical scientists work together to develop a Systems Medicine approach to study early and advanced liver disease. The aim of this unique research program is to acquire and use new experimental data and data from existing data bases to build ...

Projects: Early Metabolic Injury (LiSyM-EMI - Pillar I), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), LiSyM Core Infrastructure and Management (LiSyM-PD), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), FAIRDOM & LiSyM & de.NBI Data Structuring Training, New LiSyM project

Web page: http://www.lisym.org

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Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

We will contribute to the LiSyM Research Network an open source, freely available and reproducible multiscale model of the human liver from single cell metabolism to whole liver function. The model will be available in existing standards of systems biology, provide standardized interfaces for data integration and be fully annotated to available biological, medical and computational ontologies. All data, models and source code will be shared within the LiSyM Research Network and made available to ...

Programme: LiSyM - Systems Medicine of the Liver

Public web page: https://livermetabolism.com

Organisms: Homo sapiens, Mus musculus, Rattus norvegicus

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MM-PLF: Multiscale modeling for personalized liver function

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

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Matthias König

Understanding how liver function arises from the complex interaction of morphology, perfusion, and metabolism from single cells up to the entire organ requires systems-levels computational approaches.