Falk Schreiber

Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.

We performed topological analysis on the diagrams of the COVID-19 DM repository using the tool Vanted / SBGN-ED, which supports the import and export of several standard formats (such as SBML, SBGN-ML, and GML).

To allow detailed visual analysis of the overall system and its parts, we used a customised version of our Vanted extension LMME (Large Metabolic Model Explorer) to construct an overview graph, showing one node per pathway and the respective interconnecting species. We performed a comprehensive analysis of node centralities on two levels: on the level of the individual pathway networks as well as on the level of an aggregated network which is composed of the individual networks. This allows ...

Pathway: Assembly of the Replication Transcription Complex and Transcription