Glucose metabolism in cancer cell lines
OverviewUp-regulation of glycolytic flux (glucose to lactate conversion), also known as the “Warburg effect”, has been associated with 90% of cancers. We implemented a systems biology approach in order to improve the overall understanding of the “Warburg effect” as well as identifying drug targets within the glycolytic pathway.
Programme: SARCHI: Mechanistic modelling of health and epidemiology
SEEK ID: https://fairdomhub.org/projects/336
Public web page: Not specified
Organisms: Homo sapiens
FAIRDOM PALs: No PALs for this Project
Project created: 23rd Jan 2023
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Projects: SulfoSys, SulfoSys - Biotec, Glucose metabolism in cancer cell lines
Institutions: University Duisburg-Essen, Stellenbosch University
Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications, SCyCode The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers, Project Coordination, WP 3: Drug release kinetics study, Glucose metabolism in cancer cell lines
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, University of Manchester - Department of Computer Science, Stellenbosch University
The Snoep Lab’s core research efforts are in Computational Systems Biology; a combined experimental, modeling and theoretical approach to quantitatively understand the functional behavior of Biological Systems resulting from the characteristics of their components. Our main focus is on metabolism, of human pathogens such as Plasmodium falciparum, Mycobacterium tuberculosis, but also of breast cancer cell lines, and on modelling disease states such as glucose homeostatis in type 2 diabetes, and ...
Projects: Whole body modelling of glucose metabolism in malaria patients, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications, Glucose metabolism in cancer cell lines
Web page: http://www.sun.ac.za/english/faculty/science/biochemistry/research/snoep-group
Submitter: Theresa Kouril
Studies: 3-Bromopyruvate (3BrP) titrations, Data analysis and calculation of control coefficients, Iodoacetic acid (IAA) titrations in cancer cell lines
Assays: GAPDH and flux inhibition in MCF7 and MDA231cells, HK, GAPDH and flux inhibition in MDA231 cells, Incubation time for inhibitor treatment, Target verification/ Specificity of 3BrP in glycolysis, Traget verification/ Specificity of IAA in glycolysis
Submitter: Theresa Kouril
Investigation: Metabolic control analysis of glyceraldehyde 3-...
Assays: No Assays
Submitter: Theresa Kouril
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Metabolic control analysis of glyceraldehyde 3-...
Submitter: Theresa Kouril
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Metabolic control analysis of glyceraldehyde 3-...
Submitter: Theresa Kouril
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Metabolic control analysis of glyceraldehyde 3-...
Submitter: Theresa Kouril
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Metabolic control analysis of glyceraldehyde 3-...
Submitter: Theresa Kouril
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Metabolic control analysis of glyceraldehyde 3-...
Creator: Theresa Kouril
Submitter: Theresa Kouril
DownloadCreator: Theresa Kouril
Submitter: Theresa Kouril
Creator: Theresa Kouril
Submitter: Theresa Kouril
Creator: Theresa Kouril
Submitter: Theresa Kouril
Creator: Theresa Kouril
Submitter: Theresa Kouril
Creator: Theresa Kouril
Submitter: Theresa Kouril
Creator: Theresa Kouril
Submitter: Theresa Kouril
Creator: Theresa Kouril
Submitter: Theresa Kouril
Creator: Theresa Kouril
Submitter: Theresa Kouril
Creator: Theresa Kouril
Submitter: Theresa Kouril
Abstract
Authors: Theresa Kouril, Craig October, Stephanie Hollocks, Christoff Odendaal, David D. van Niekerk, Jacky L. Snoep
Date Published: 1st Sep 2023
Publication Type: Journal
