iPlacenta: A European Union Horizon 2020 innovative training network (ITN)
The principal research aim of iPLACENTA is to improve our ability to study, model and visualise the placenta. This will contribute to developing diagnostic tests and therapies for pregnancy complications such as preeclampsia and intrauterine growth restriction (IUGR). Placental defects are thought to be the cause of many major pregnancy complications, such as preeclampsia and intra-uterine growth restriction. Preeclampsia affects between 5 and 8 out of every 100 pregnant women and claims the lives of 76,000 mothers and 500,000 babies annually. Intrauterine growth restriction affects 60,000 births across the EU per year. This is the most common factor for stillborn babies. Yet the low prediction rate means that it often leads to the pre-emptive induction of labour at a premature stage, when it could have been delayed. For the mothers and children that survive preeclampsia and intrauterine growth restriction, there are life-long serious cardiovascular and neurological consequences.
Web page: https://www.iplacenta.eu/
Funding codes:- Marie Skłodowska-Curie grant agreement No. 765274
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 765274.
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Projects: COVID-19 Disease Map, Molecular characterization and angiogenic properties of extracellular vesicles in healthy and preeclamptic amniotic fluid, Overexpression of microRNAs miR-25-3p, miR-185-5p and miR-132-3p in Late Onset Fetal Growth Restriction, Validation of Results and Study of the Biochemical Pathways Involved, Comparative Proteome Profile of Placental Sub-anatomical regions, The deregulated interplay of complement system and antioxidant activity as a driver of adverse pregnancy outcomes
Institutions: University of Rostock, Instituto de Investigación Sanitaria La Fe
https://orcid.org/0000-0002-0034-7755
The placenta remains the key to maternal diseases such as Pre-eclampsia (PE) and Intrauterine growth restriction (IUGR), however the pathophysiology of these disorders remains elusive. The aim of this study is to characterize the key proteomic variations between PE and IUGR, to better understand the pathoetiology of these diseases.Term placentas each were collected from PE, IUGR pregnancies, and age and BMI matched healthy controls. Quadrupole-orbitrap mass spectrometer was used in data dependent ...
Programme: iPlacenta: A European Union Horizon 2020 innovative training network (ITN)
Public web page: Not specified
Placental dysfunction has been associated with various pregnancy complications leading to both maternal and fetal death and long-term consequences, however, the placenta is one of the least studied organs within the human body. In this pilot study, protein signature of three healthy placentae was measured using label free quantification mass spectrometry. Each placenta was sampled in five sample sites and three sub-anatomical regions. Differentially expressed proteins were identified considering ...
Programme: iPlacenta: A European Union Horizon 2020 innovative training network (ITN)
Public web page: Not specified
Programme: iPlacenta: A European Union Horizon 2020 innovative training network (ITN)
Public web page: Not specified
Complete list of differentially expressed proteins between sub-anatomical regions. Non significant results were filtered out.
Creators: None
Submitter: Julia Scheel
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Complete list of differentially expressed proteins between sub-anatomical regions. Non significant results were filtered out.
Creators: None
Submitter: Julia Scheel
Creator: Natalia Gebara
Submitter: Natalia Gebara
Creator: Natalia Gebara
Submitter: Natalia Gebara
Creator: Natalia Gebara
Submitter: Natalia Gebara
Creator: Natalia Gebara
Submitter: Natalia Gebara
Creator: Natalia Gebara
Submitter: Natalia Gebara
Creator: Natalia Gebara
Submitter: Natalia Gebara
Creator: Natalia Gebara
Submitter: Natalia Gebara
Creator: Natalia Gebara
Submitter: Natalia Gebara
Creator: Natalia Gebara
Submitter: Natalia Gebara
Creator: Natalia Gebara
Submitter: Natalia Gebara
Creator: Natalia Gebara
Submitter: Natalia Gebara
Description of PCR validation results expressed as 2 -ΔΔCt of miR 25-3p, miR 185-5p and miR 132-3p
Creator: Gabriela Loscalzo
Submitter: Gabriela Loscalzo
Description of PCR validation results expressed as 2 -ΔΔCt of miR 25-3p, miR 185-5p and miR 132-3p
Creator: Gabriela Loscalzo
Submitter: Gabriela Loscalzo
Description of PCR validation results expressed as 2 -ΔΔCt of miR 25-3p, miR 185-5p and miR 132-3p
Creator: Gabriela Loscalzo
Submitter: Gabriela Loscalzo
It is a description of the maternal clinical data, fetal Doppler ultrasound data and delivery data of both groups of cases (late-onset fetal growth restriction) and controls (normal growth).
Creator: Gabriela Loscalzo
Submitter: Gabriela Loscalzo
It is a description of the maternal clinical data, fetal Doppler ultrasound data and delivery data of both groups of cases (late-onset fetal growth restriction) and controls (normal growth).
Creator: Gabriela Loscalzo
Submitter: Gabriela Loscalzo
Samples underwent size exclusion chromoatography
Creator: Natalia Gebara
Submitter: Natalia Gebara
Full list of detected miRNA which were found to be deregulated in PE-EVs.
Creator: Natalia Gebara
Submitter: Natalia Gebara
