Morpheus model of spatio-temporal YAP/Hippo pathway activation during liver regeneration Version 1
For the spatio-temporal dynamics of bile transport, bile canalicular dilation, mechanical stimulation and transduction of YAP signaling during liver regeneration see the open access publication and its appendix: Meyer et al. (2020) Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration. Molecular Systems Biology 16:e8985. https://doi.org/10.15252/msb.20198985
The model format is MorpheusML that can readily be loaded and run in the free and open source software Morpheus: https://morpheus.gitlab.io This simulation yields a movie of the spatio-temporal dynamics of total and nuclear YAP in a file of cells.
SEEK ID: https://fairdomhub.org/models/760?version=1
1 item (and an image) are associated with this Model:-
YAP_Signaling_Liver_Regeneration.xml (XML document - 11.2 KB)
Organism: Mus musculus
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Execution or visualisation environment: Not specified
Model image: (Click on the image to zoom) (Original)
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Creators and Submitter
Views: 1470 Downloads: 51
Created: 27th Nov 2020 at 17:04
Last updated: 27th Nov 2020 at 17:04
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Version 1 (earliest) Created 27th Nov 2020 at 17:04 by Lutz Brusch
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https://orcid.org/0000-0003-0137-5106Lutz Brusch is heading the research group "Spatio-temporal pattern formation in cells and tissues" at the Centre for Information Services and High Performance Computing of TU Dresden, Germany. The group is co-developing the multi-cellular modelling and simulation framework Morpheus (https://morpheus.gitlab.io) and is collaborating with experimental labs on questions of tissue morphogenesis and regeneration.
This is the exchange platform of the COMBINE network.
COMBINE is an initiative to coordinate the development of various community standards and formats for computational models: BioPax, CellML, NeuroML, Synthetic Biology Open Language (SBOL), Systems Biology Graphical Notation (SBGN), Systems Biology Markup Language (SBML), Simulation Experiment Description Markup Language (SED-ML).
Projects: COMBINE Multicellular Modelling, ModeleXchange initiative
Web page: http://co.mbine.org
LiSyM (Liver Systems Medicine) represents a research network of German centers and institutions, brought together by a 20 Million Euro funding program of the German Government, in which mathematicians, modelers, pharmacologists, molecular biologists and clinical scientists work together to develop a Systems Medicine approach to study early and advanced liver disease. The aim of this unique research program is to acquire and use new experimental data and data from existing data bases to build ...
Projects: Early Metabolic Injury (LiSyM-EMI - Pillar I), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), LiSyM Core Infrastructure and Management (LiSyM-PD), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), FAIRDOM & LiSyM & de.NBI Data Structuring Training, New LiSyM project
Web page: http://www.lisym.org
Programme: COMBINE (Computational Modeling in Biology Network)
Public web page: https://multicellml.org/
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Abstract (Expand)
Authors: K. Meyer, H. Morales-Navarrete, S. Seifert, M. Wilsch-Braeuninger, U. Dahmen, E. M. Tanaka, L. Brusch, Y. Kalaidzidis, M. Zerial
Date Published: 25th Feb 2020
Publication Type: Journal
