Full title: Spatio-temporal model of YAP signaling in hepatocytes after partial hepatectomy.
Date: 28.6.2018
Author: lutz.brusch@tu-dresden.de
Software: Morpheus (open-source), download from https://morpheus.gitlab.io
Reference: This model is described in the peer-reviewed publication "Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration" by Kirstin Meyer, Hernan Morales-Navarrete, Sarah Seifert, Michaela Wilsch-Braeuninger, Uta Dahmen, Elly M. Tanaka, Lutz Brusch, Yannis Kalaidzidis and Marino Zerial. Molecular Systems Biology
16:e8985, 2020.
https://doi.org/10.15252/msb.20198985
YAP signaling
1
- C * Michaelis_Menten(SENSOR / C, Km, V) + C * Michaelis_Menten(inact_SENSOR / C, Km_1, Tension)
C * Michaelis_Menten(SENSOR / C, Km, V) - C * Michaelis_Menten(inact_SENSOR / C, Km_1, Tension)
k5 * inact_YAP - k4 * YAP * inact_SENSOR / C - k10 * YAP - k9 * YAP + k8 * N_YAP * N + C * k3_0 * s
- k11 * inact_YAP - k5 * inact_YAP + k4 * YAP * inact_SENSOR / C - k6 * inact_YAP + k7 * inact_YAP_SF
k6 * inact_YAP - k7 * inact_YAP_SF
k9 * YAP / N - k8 * N_YAP
time>0.4
if(cell.id==1,1.8279930944312834,
if(cell.id==2,1.7866460754759526,
if(cell.id==3,1.8374519069180288,
if(cell.id==4,1.8640351995565263,
if(cell.id==5,1.8706834857072998,
if(cell.id==6,1.8941858816263410,
if(cell.id==7,1.8511397598872272,
if(cell.id==8,1.9135216039396319,
if(cell.id==9,1.9145071129239710,
if(cell.id==10,1.8153404444156003,
1))))))))))
time>1.15
if(cell.id==1,1.9807223334150590,
if(cell.id==2,1.9130780850583866,
if(cell.id==3,1.9643577716468286,
if(cell.id==4,2.0020827404251120,
if(cell.id==5,2.0252154507264140,
if(cell.id==6,2.0703197134079440,
if(cell.id==7,1.9915999174723278,
if(cell.id==8,2.0046213799240973,
if(cell.id==9,1.9540901073551358,
if(cell.id==10,1.8753435897018356,
1))))))))))
time>1.75
if(cell.id==1,2.0217009184038360,
if(cell.id==2,1.9258181971655592,
if(cell.id==3,1.9518589890960070,
if(cell.id==4,1.9123363331127760,
if(cell.id==5,2.0319328550271623,
if(cell.id==6,2.0158606286091496,
if(cell.id==7,1.9434430184290816,
if(cell.id==8,1.8907841188362082,
if(cell.id==9,1.9473574849407167,
if(cell.id==10,1.8715472190966007,
1))))))))))
time>2.5
if(cell.id==1,1.8597267890032976,
if(cell.id==2,1.7814702267887177,
if(cell.id==3,1.8292379408251978,
if(cell.id==4,1.8488155708410638,
if(cell.id==5,1.8536661678277864,
if(cell.id==6,1.8836145987139055,
if(cell.id==7,1.8442276337980785,
if(cell.id==8,1.8136740374044704,
if(cell.id==9,1.8868282103886570,
if(cell.id==10,1.8015329680486330,
1))))))))))
time>4.0
if(cell.id==1,1.9088767623308390,
if(cell.id==2,1.8488496952244589,
if(cell.id==3,1.8616629446112190,
if(cell.id==4,1.8244687794620162,
if(cell.id==5,1.8557929833228486,
if(cell.id==6,1.8447542721681303,
if(cell.id==7,1.7726695922335742,
if(cell.id==8,1.7074409071843903,
if(cell.id==9,1.7730171801027250,
if(cell.id==10,1.7408530847107613,
1))))))))))
V * substrate / (Km + substrate)
(YAP + inact_YAP + inact_YAP_SF) / C
(C * C_YAP_total + N * N_YAP) / (C + N)