Morpheus model of spatio-temporal liver zonation from Wnt-Hh crosstalk
Version 1

Spatio-temporal liver zonation in mouse and human with Wnt-Hh crosstalk and transport are modeled using coupled partial differential equations. The model file is in MorpheusML format and can be opened in the free, open-source multicellular modeling software Morpheus ( In Morpheus, the model will simulate the time course (movie) of dynamic liver zonation for a 2D cross-section of several liver lobules, showing the patterns of Wnt ligands, intracellular Wnt signaling, IHH, SHH, GLI3. The final state of this spatio-temporal simulation reproduces the control condition in Figure 5B of the publication (Kolbe et al., 2019).


1 item (and an image) are associated with this Model:
  • Spatio-temporal-model-of-liver-zonation-MorpheusML.xml (XML document - 6.23 KB) Download

Organism: Mus musculus

Model type: Partial differential equations (PDE)

Model format: Not specified

Execution or visualisation environment: Not specified

Model image: (Click on the image to zoom) (Original)

help Creators and Submitter
Additional credit

Michael Kücken


Views: 1084   Downloads: 28

Created: 27th Nov 2020 at 16:38

Last updated: 27th Nov 2020 at 16:54

help Tags

Version History

Version 1 (earliest) Created 27th Nov 2020 at 16:38 by Lutz Brusch

No revision comments

Powered by
Copyright © 2008 - 2023 The University of Manchester and HITS gGmbH