Spatio-temporal liver zonation in mouse and human with Wnt-Hh crosstalk and transport are modeled using coupled partial differential equations. The model file is in MorpheusML format and can be opened in the free, open-source multicellular modeling software Morpheus (https://morpheus.gitlab.io). In Morpheus, the model will simulate the time course (movie) of dynamic liver zonation for a 2D cross-section of several liver lobules, showing the patterns of Wnt ligands, intracellular Wnt signaling, IHH, SHH, GLI3. The final state of this spatio-temporal simulation reproduces the control condition in Figure 5B of the publication (Kolbe et al., 2019).
Organism: Mus musculus
Model type: Partial differential equations (PDE)
Model format: Not specified
Execution or visualisation environment: Not specified
Model image: (Click on the image to zoom) (Original)