Morpheus model of spatio-temporal Smo regulation in response to Hh signaling Version 1
The model is adapted from A.P. Kupinski, I. Raabe, M. Michel, D. Ail, L. Brusch, T. Weidemann, C. Bökel (2013) Phosphorylation of the Smo tail is controlled by membrane localization and is dispensable for clustering, J. Cell Sci., 126, 20, 4684-4697 doi: 10.1242/jcs.128926
The model format is MorpheusML that can readily be loaded and run in Morpheus: https://imc.zih.tu-dresden.de//wiki/morpheus
SEEK ID: https://fairdomhub.org/models/321?version=1
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endocytosis_and_signaling_Morpheus.xml (XML document - 4 KB)
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Created: 8th Jun 2018 at 15:55
Last updated: 8th Jun 2018 at 15:55
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Version 1 (earliest) Created 8th Jun 2018 at 15:55 by Lutz Brusch
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https://orcid.org/0000-0003-0137-5106Lutz Brusch is heading the research group "Spatio-temporal pattern formation in cells and tissues" at the Centre for Information Services and High Performance Computing of TU Dresden, Germany. The group is co-developing the multi-cellular modelling and simulation framework Morpheus (https://morpheus.gitlab.io) and is collaborating with experimental labs on questions of tissue morphogenesis and regeneration.
LiSyM (Liver Systems Medicine) represents a research network of German centers and institutions, brought together by a 20 Million Euro funding program of the German Government, in which mathematicians, modelers, pharmacologists, molecular biologists and clinical scientists work together to develop a Systems Medicine approach to study early and advanced liver disease. The aim of this unique research program is to acquire and use new experimental data and data from existing data bases to build ...
Projects: Early Metabolic Injury (LiSyM-EMI - Pillar I), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), LiSyM Core Infrastructure and Management (LiSyM-PD), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), FAIRDOM & LiSyM & de.NBI Data Structuring Training, New LiSyM project
Web page: http://www.lisym.org
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Abstract (Expand)
Authors: J. Starruss, W. de Back, L. Brusch, A. Deutsch
Date Published: No date defined
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