Transcriptomic profiling across the spectrum of non-alcoholic fatty liver disease
Version 1

In this study, we used publically available dataset from gene expression omnibus (GEO):

The pathophysiological mechanisms that drive non-alcoholic fatty liver disease (NAFLD) progression remain poorly understood. This multicenter study characterized the transcriptional changes that occur as liver disease progresses. 216 snap frozen liver biopsies, comprising 206 NAFLD cases with different fibrosis stages and 10 controls were studied. Samples underwent high-throughput RNA sequencing. This study provides novel insights into transcriptional changes during liver disease evolution and progression as well as proof of principle that transcriptomic changes reveal potentially tractable biomarkers for NAFLD fibrosis. Overall design: 216 snap-frozen biopsies were processed for RNA sequencing on the Illumina NextSeq 500 system.

help Creators and Submitter
Creators
Not specified
Additional credit

Govaere O et.al.

Submitter
Activity

Views: 255

Created: 25th Nov 2021 at 12:10

Last updated: 25th Nov 2021 at 15:50

Last used: 25th May 2022 at 17:04

help Tags

This item has not yet been tagged.

help Attributions

None

Version History

Version 1 Created 25th Nov 2021 at 12:10 by Hong Yang

No revision comments

Powered by
(v.1.12.0)
Copyright © 2008 - 2022 The University of Manchester and HITS gGmbH

By continuing to use this site you agree to the use of cookies