Inken Wohlers

This project contains molecular QTL analyses related to lung health and asthma in the ERA/ALLIANCE cohort, including cis-eQTL and cis-mQTL mapping, associated preprocessing and quality control, and downstream characterization of genetic effects on gene expression and DNA methylation.

Medulloblastoma represents the most frequent malignant brain tumor in children, occurring in the cerebellum. At diagnosis, approximately 30% of patients show disseminated (metastatic) disease. Approximately 60% survival can be reached with multimodal treatment including operation, irradiation and chemotherapy. However, survivors suffer from significant side effects, including neurocognitive impairment, which is very severe in young age when the central nervous system is still developing. To reduce ...

Mission: We perform cutting-edge research on data generated by novel biomolecular technologies to address questions in pneumology. Towards this, we use biological high-throughput data, i.e., OMICs data, to gain insights into molecular and phenotypic traits and diseases using computational methods. We combine data, methodology and their applications in pneumology through interdisciplinary collaboration with mathematicians, computer scientists, biologists and physicians.

Background: The immunoproteasome is expressed constitutively in immune cells alongside standard proteasomes and forms multiple mixed types of proteasome complexes. These mixed 20S proteasomes may have distinct proteolytic activities depending on their subunit composition and may thereby regulate immune cell function. Using site-specific versus pan-inhibitors of the immunoproteasome, we here aim to dissect the biological functions of the three active sites of the immunoproteasome for monocyte cell ...

The conditions are Control: Control (no stimulation, no TLR8 inhibition) Inhib: TLR8 inhibition Msm: Methanobrevibacter smithii stimulation Mst: Methanosphaera stadtmanae stimulation Msm_Inhib: Methanobrevibacter smithii stimulation and TLR8 inhibition Mst_Inhib: Methanosphaera stadtmanae stimulation and TLR8 inhibition

Illumina RNA Sequencing of human PBMCs of 9 donors stimulated with two archaea, measured after 4 and 24 hours as well as without stimulation after 24 hours as control

This compares the five conditions Control at 24 hours, Methanobrevibacter smithii (MBS) at 4 and 24 hours, Methanosphaera stadtmanae (MSS) at 4 and 24 hours in a joint model. The respective conditions are abbreviated Control_24h, MBS_4h, MBS_24h, MSS_4h, MSS_24h

The base condition is C3, i.e. differences are in relation to C3.

Base level is C3, i.e. differences are in relation to C3.

C3 is base condition, i.e. differences are in relation to C3.

C2 is the base condition, i.e. the differences are C1 in relation to C2.