Leif Steil
I started to work with B. subtilis during my diploma thesis in Marburg, analyzing the gene expression pattern during sporulation and their control by the four sporulation sigma factors. This work was continued during my PhD thesis in Greifswald. In collaboration with Prof. Bremer and Prof. Marahiel in Marburg we also studied additional adaptation processes of B. subtilis, like the adaptation to low temperatur and high osmolarity. I am now working as a staff scientist in Prof. Völkers lab in Greifswald. Here I am involved in Transcriptome and Proteome analysis in a variety of projects. In this context I am also engaged in data storage and data analysis issues here in our institute. Thats why I was asked to work as PAL for the BaCell-Sysmo consortium.
SEEK ID: https://fairdomhub.org/people/194
Location:
Germany
ORCID: Not specified
Joined: 17th Feb 2009
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SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".
The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.
Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...
Projects: BaCell-SysMO, COSMIC, SUMO, KOSMOBAC, SysMO-LAB, PSYSMO, SCaRAB, MOSES, TRANSLUCENT, STREAM, SulfoSys, SysMO DB, SysMO Funders, SilicoTryp, Noisy-Strep
Web page: http://sysmo.net/
BaCell-SysMO 2 Modelling carbon core metabolism in Bacillus subtilis – Exploring the contribution of protein complexes in core carbon and nitrogen metabolism.
Bacillus subtilis is a prime model organism for systems biology approaches because it is one of the most advanced models for functional genomics. Furthermore, comprehensive information on cell and molecular biology, physiology and genetics is available and the European Bacillus community (BACELL) has a well-established reputation for applying ...
Programme: SysMO
Public web page: http://www.sysmo.net/index.php?index=53
RNA processing and degradation is initiated by endonucleolytic cleavage of the target RNAs. In many bacteria, this activity is performed by RNase E which is not present in Bacillus subtilis and other Gram-positive bacteria. Recently, the essential endoribonuclease RNase Y has been discovered in B. subtilis. This RNase is involved in the degradation of bulk mRNA suggesting a major role in mRNA metabolism. However, only a few targets of RNase Y have been identified so far. In order to assess the ...
Creators: None
Submitter: Leif Steil
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In Bacillus subtilis and its relatives carbon catabolite control, a mechanism enabling to reach maximal efficiency of carbon and energy sources metabolism, is achieved by the global regulator CcpA (carbon catabolite protein A). CcpA in a complex with HPr-Ser-P (seryl-phosphorylated form of histidine-containing protein, HPr) binds to operator sites called catabolite responsive elements, cre. Depending on the cre box position relative to the promoter, the CcpA/HPr-Ser-P complex can either act as a ...
Creator: Oscar Kuipers
Submitter: Leif Steil
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Table describing the catabolite repression of β-xylosidase by different carbon sources(glucose, sorbitol, fructose, maltose, glycerol. mannitol) in various mutants of CcpA cofactors (HprK, crh)
Creator: Joerg Stuelke
Submitter: Leif Steil
Creator: Joerg Stuelke
Submitter: Leif Steil
Recent studies revealed the unsuspected complexity of the bacterial transcriptome but its systematic analysis across many diverse conditions remains a challenge. Here we report the condition-dependent transcriptome of the prototype strain B. subtilis 168 across 104 conditions reflecting the bacterium's life-styles. This data set composed of 269 tiling array hybridizations allowed to observe ~85% of the annotated CDSs expressed in the higher 30% in at least one hybridization and thus provide an ...
Creators: Leif Steil, Ulrike Mäder, Colin Harwood, Rick Lewis, Ruben Mars, Priyanka Nannapaneni, Praveen kumar Sappa, Joerg Stuelke, Jan Maarten van Dijl, Michael Hecker, Uwe Voelker
Submitter: Leif Steil
List of protein identified proteins in SPINE experiment.
Creators: Joerg Stuelke, Uwe Voelker
Submitter: Leif Steil
Creator: Joerg Stuelke
Submitter: Leif Steil
mRNAs with decreased abundance in all replicates with an average fold change of at least 1.5
Creators: None
Submitter: Leif Steil
Creators: Joerg Stuelke, Rick Lewis, joseph newman
Submitter: Leif Steil
Phosphorylation site of the HPr protein detected ba mass spectromety
Creators: Michael Hecker, Joerg Stuelke
Submitter: Leif Steil
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Authors: Vivianne J Goosens, Andreas Otto, Corinna Glasner, Carmine G Monteferrante, René van der Ploeg, , Dörte Becher,
Date Published: 22nd Dec 2012
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Authors: Martin Lehnik-Habrink, Leonie Rempeters, Akos T Kovács, Christoph Wrede, Claudia Baierlein, Heike Krebber, ,
Date Published: 24th Nov 2012
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Authors: , Annette Wensing, Margot Brosius, , ,
Date Published: 24th Nov 2012
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Date Published: 10th Nov 2012
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Authors: , Monika Pabijaniak, Anne de Jong, Robert Dűhring, , ,
Date Published: 17th Aug 2012
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Authors: , Carsten von Blohn, Agnieszka Stanek, Susanne Moses, Helena Barzantny,
Date Published: 8th Jun 2012
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Authors: Martin Lehnik-Habrink, , ,
Date Published: 8th May 2012
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Authors: Pierre Nicolas, , Etienne Dervyn, Tatiana Rochat, Aurélie Leduc, Nathalie Pigeonneau, Elena Bidnenko, Elodie Marchadier, Mark Hoebeke, Stéphane Aymerich, Dörte Becher, Paola Bisicchia, Eric Botella, Olivier Delumeau, Geoff Doherty, Emma L Denham, Mark J Fogg, Vincent Fromion, Anne Goelzer, Annette Hansen, Elisabeth Härtig, , Georg Homuth, Hanne Jarmer, Matthieu Jules, Edda Klipp, Ludovic Le Chat, François Lecointe, , Wolfram Liebermeister, Anika March, , , David Noone, Susanne Pohl, Bernd Rinn, Frank Rügheimer, , Franck Samson, Marc Schaffer, Benno Schwikowski, , , Thomas Wiegert, Kevin M Devine, Anthony J Wilkinson, , , , Philippe Bessières, Philippe Noirot
Date Published: 3rd Mar 2012
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Authors: , , , , Georg Homuth, ,
Date Published: 2012
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Authors: , Lorraine Hewitt, Cecilia Rodrigues, Alexandra S Solovyova, ,
Date Published: 16th Dec 2011
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Authors: Katrin Gunka, Stefan Tholen, Jan Gerwig, Christina Herzberg, , Fabian M Commichau
Date Published: 16th Dec 2011
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Authors: Jens J Landmann, Susanne Werner, , , Boris Görke
Date Published: 28th Nov 2011
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Authors: , Arne G Schmeisky, ,
Date Published: 16th Nov 2011
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Authors: Frederik M Meyer, Matthieu Jules, Felix M P Mehne, Dominique Le Coq, Jens J Landmann, Boris Görke, Stéphane Aymerich,
Date Published: 14th Oct 2011
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Authors: Hamidreza Fasehee, Helga Westers, Albert Bolhuis, Haike Antelmann, , Wim J Quax, Agha F Mirlohi, , Gholamreza Ahmadian
Date Published: 31st Aug 2011
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Authors: Martin Lehnik-Habrink, Marc Schaffer, , Christine Diethmaier, Christina Herzberg,
Date Published: 4th Aug 2011
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Authors: Martin Lehnik-Habrink, , Fabian M Rothe, Alexandra S Solovyova, Cecilia Rodrigues, Christina Herzberg, Fabian M Commichau, ,
Date Published: 29th Jul 2011
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Authors: Jeanette Brill, , Monika Bleisteiner,
Date Published: 22nd Jul 2011
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Authors: Manuel Liebeke, Kirsten Dörries, Daniela Zühlke, Jörg Bernhardt, Stephan Fuchs, Jan Pané-Farré, Susanne Engelmann, , Rüdiger Bode, Thomas Dandekar, Ulrike Lindequist, ,
Date Published: 1st Apr 2011
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