Gerald Seidel
I studied chemistry in Erlangen and started research on carbon catabolite regulation in Bacillus megaterium in my diploma thesis. During my PhD thesis I was concerned with quantitative analyses of protein-protein and protein-DNA interactions of CcpA, in vivo- and in vitro-characterization of point mutants of CcpA and coeffectors and I contributed to the structural analysis of different CcpA complexes. During a postdoctoral appointment I focused on interaction analyses of PrfA, a regulator of listerial virulence genes. After this appointment I developed serological tests at Viramed Biotech AG in Planegg. Recently, I moved back to Erlangen for a position as academical manager. There, one of my tasks is the scientific support of the CcpA-group.
SEEK ID: https://fairdomhub.org/people/288
Location:
Germany
ORCID: Not specified
Joined: 24th Apr 2009
Expertise: carbon catabolite regulation in Gram positive bacteria, interaction analyses of transcriptional regulators, analysis and preparation of diagnostic markers for Helicobacter pylori infections Yersiniosis and collagenoses
Tools: molecular biological, microbiological and immunological techniques, interaction analysis techniques especially SPR measurements
Their tagsRelated items
SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".
The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.
Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...
Projects: BaCell-SysMO, COSMIC, SUMO, KOSMOBAC, SysMO-LAB, PSYSMO, SCaRAB, MOSES, TRANSLUCENT, STREAM, SulfoSys, SysMO DB, SysMO Funders, SilicoTryp, Noisy-Strep
Web page: http://sysmo.net/
BaCell-SysMO 2 Modelling carbon core metabolism in Bacillus subtilis – Exploring the contribution of protein complexes in core carbon and nitrogen metabolism.
Bacillus subtilis is a prime model organism for systems biology approaches because it is one of the most advanced models for functional genomics. Furthermore, comprehensive information on cell and molecular biology, physiology and genetics is available and the European Bacillus community (BACELL) has a well-established reputation for applying ...
Programme: SysMO
Public web page: http://www.sysmo.net/index.php?index=53
The aim of this project is to develop a detailed kinetic model of the CcpA-dependent regulatory network, the key regulon of flux regulation in B. subtilis. Thereby involved are more than 300 genes e.g. catabolism, overflow metabolism, the TCA cycle and amino acid anabolism which are regulated via carbon catabolite regulation (CCR)
Submitter: Gerald Seidel
Investigation: A dynamic model of the CcpA regulation network
Assays: Binding constants for CcpA with HPrSer46P interacting with various cre-e...
Abstract (Expand)
Authors: , Monika Pabijaniak, Anne de Jong, Robert Dűhring, , ,
Date Published: 17th Aug 2012
Publication Type: Not specified
Abstract (Expand)
Authors: Andrea Wünsche, Elke Hammer, , , Andreas Burkovski, ,
Date Published: 20th Apr 2012
Publication Type: Not specified
