Abstract (Expand)

Nucleic acids, which constitute the genetic material of all organisms, are continuously exposed to endogenous and exogenous damaging agents, representing a significant challenge to genome stability and ...

Authors: Nima Borhan Fakouri, Jon Ambæk Durhuus, Christine Elisabeth Regnell, Maria Angleys, Claus Desler, Md Mahdi Hasan-Olive, Ana Martín-Pardillos, Anastasia Tsaalbi-Shtylik, Kirsten Thomsen, Martin Lauritzen, Vilhelm A. Bohr, Niels de Wind, Linda Hildegard Bergersen, Tim Rasmussen

Date Published: 1st Dec 2017

Journal: Sci Rep

Abstract (Expand)

Sustainable production of target compounds such as biofuels and high-value chemicals for pharmaceutical, agrochemical, and chemical industries is becoming an increasing priority given their current ...

Authors: Natalie Stanford, P. Millard, N. Swainston

Date Published: 24th Mar 2015

Journal: Front Cell Dev Biol

Abstract (Expand)

In many plants, starch is synthesized during the day and degraded during the night to avoid carbohydrate starvation in darkness. The circadian clock participates in a dynamic adjustment of starch ...

Authors: Daniel Seaton, O. Ebenhoh, Andrew Millar, A. Pokhilko

Date Published: 18th Dec 2013

Journal: J R Soc Interface


Not specified

Authors: Anna Feldman-Salit, Silvio Hering, H. Messiha, Nadine Veith, Vlad Cojocaru, Antje Sieg, Hans Westerhoff, Bernd Kreikemeyer, Rebecca Wade, Tomas Fiedler

Date Published: 17th May 2013

Journal: Journal of Biological Chemistry

Abstract (Expand)

Plant and microbial metabolic engineering is commonly used in the production of functional foods and quality trait improvement. Computational model-based approaches have been used in this important ...

Author: M. Bekaert

Date Published: 14th Nov 2012

Journal: PLoS One

Abstract (Expand)

RNA processing and degradation are key processes in the control of transcript accumulation and thus in the control of gene expression. In Escherichia coli, the underlying mechanisms and components of ...

Authors: Martin Lehnik-Habrink, Rick Lewis, Ulrike Mäder, Joerg Stuelke

Date Published: 8th May 2012

Journal: Mol. Microbiol.

Abstract (Expand)

Lactic acid-producing bacteria survive in distinct environments, but show common metabolic characteristics. Here we studied the dynamic interactions of the central metabolism in Lactococcus lactis, ...

Authors: None

Date Published: 14th Feb 2012

Journal: The FEBS journal

Abstract (Expand)

RightField is a Java application that provides a mechanism for embedding ontology annotation support for scientific data in Microsoft Excel or Open Office spreadsheets. The result is semantic annotation ...

Authors: Katy Wolstencroft, Stuart Owen, Matthew Horridge, Wolfgang Müller, Finn Bacall, Jacky Snoep, Franco du Preez, Quyen Nguyen, Olga Krebs, Carole Goble

Date Published: 2012

Journal: Knowledge Engineering and Knowledge Management

Abstract (Expand)

The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments. The recently published ...

Authors: Dagmar Waltemath, Richard Adams, Frank T Bergmann, Michael Hucka, Fedor Kolpakov, Andrew K Miller, Ion I Moraru, David Nickerson, Sven Sahle, Jacky Snoep, Nicolas Le Novère

Date Published: 15th Dec 2011

Journal: BMC Syst Biol

Abstract (Expand)

Many bacteria undergo transitions between environments with differing O₂ availabilities as part of their natural lifestyles and during biotechnological processes. However, the dynamics of adaptation ...

Authors: Eleanor W Trotter, Matthew Rolfe, Andrea M Hounslow, C Jeremy Craven, Michael P Williamson, Guido Sanguinetti, Robert Poole, Jeff Green

Date Published: 27th Sep 2011

Journal: PLoS ONE

Abstract (Expand)

RNA processing and degradation is initiated by endonucleolytic cleavage of the target RNAs. In many bacteria, this activity is performed by RNase E which is not present in Bacillus subtilis and other ...

Authors: Martin Lehnik-Habrink, Marc Schaffer, Ulrike Mäder, Christine Diethmaier, Christina Herzberg, Joerg Stuelke

Date Published: 4th Aug 2011

Journal: Mol. Microbiol.

Abstract (Expand)

The control of mRNA stability is an important component of regulation in bacteria. Processing and degradation of mRNAs are initiated by an endonucleolytic attack, and the cleavage products are processively ...

Authors: Martin Lehnik-Habrink, Joseph Newman, Fabian M Rothe, Alexandra S Solovyova, Cecilia Rodrigues, Christina Herzberg, Fabian M Commichau, Rick Lewis, Joerg Stuelke

Date Published: 29th Jul 2011

Journal: J. Bacteriol.

Abstract (Expand)

MOTIVATION: In the Life Sciences, guidelines, checklists and ontologies describing what metadata is required for the interpretation and reuse of experimental data are emerging. Data producers, however, ...

Authors: Katy Wolstencroft, Stuart Owen, Matthew Horridge, Olga Krebs, Wolfgang Müller, Jacky Snoep, Franco Du Preez, Carole Goble

Date Published: 26th May 2011

Journal: Bioinformatics


Not specified

Authors: Matthew A. Oberhardt, Jacek Puchałka, Vitor Martins Dos Santos, Jason A. Papin

Date Published: 31st Mar 2011

Journal: PLoS Comput Biol

Abstract (Expand)

Hepatitis C virus (HCV) is a major causative agent of chronic liver disease in humans. To gain insight into host factor requirements for HCV replication, we performed a siRNA screen of the human kinome ...

Authors: S. Reiss, I. Rebhan, P. Backes, I. Romero-Brey, H. Erfle, P. Matula, Lars Kaderali, M. Poenisch, H. Blankenburg, M. S. Hiet, T. Longerich, S. Diehl, F. Ramirez, T. Balla, K. Rohr, A. Kaul, S. Buhler, R. Pepperkok, T. Lengauer, M. Albrecht, R. Eils, P. Schirmacher, V. Lohmann, Ralf Bartenschlager

Date Published: 18th Jan 2011

Journal: Cell Host Microbe

Abstract (Expand)

The important human pathogen Staphylococcus aureus is known to spread on soft agar plates. Here, we show that colony spreading of S. aureus involves the agr quorum-sensing system. This finding can be ...

Authors: Eleni Tsompanidou, Mark J J B Sibbald, Monika A Chlebowicz, Annette Dreisbach, Jaap Willem Back, Jan Maarten Van Dijl, Girbe Buist, Emma L Denham

Date Published: 17th Dec 2010

Journal: J. Bacteriol.

Abstract (Expand)

Maintenance of cation homoeostasis is a key process for any living organism. Specific mutations in Glc7, the essential catalytic subunit of yeast protein phosphatase 1, result in salt and alkaline pH ...

Authors: Jofre Ferrer-Dalmau, Asier González, Maria Platara, Clara Navarrete, José L Martínez, Lina Patricia Barreto Parra, Jose Ramos, Joaquin Ariño, Antonio Casamayor

Date Published: 24th Dec 2009

Journal: Biochem. J.

Abstract (Expand)

Various types of the staphylococcal cassette chromosome mec (SCCmec) are known to confer methicillin resistance on the human pathogen Staphylococcus aureus. Such cassettes are not always stably maintained. ...

Authors: Monika A Chlebowicz, Kristelle Nganou, Svitlana Kozytska, Jan P Arends, Susanne Engelmann, Hajo Grundmann, Knut Ohlsen, Jan Maarten Van Dijl, Girbe Buist

Date Published: 7th Dec 2009

Journal: Antimicrob. Agents Chemother.

Abstract (Expand)

Plants are exposed to continual changes in the environment. The daily alternation between light and darkness results in massive recurring changes in the carbon budget, and leads to widespread changes ...

Authors: Maria Piques, Waltraud X Schulze, Melanie Höhne, Björn Usadel, Yves Gibon, Johann Rohwer, Mark Stitt

Date Published: 13th Oct 2009

Journal: Mol Syst Biol

Abstract (Expand)

The phosphatase calcineurin and the kinases Hal4/Hal5 regulate high-affinity potassium uptake in Saccharomyces cerevisiae through the Trk1 transporter. We demonstrate that calcineurin is necessary for ...

Authors: Carlos Casado, Lynne Yenush, Carmen Melero, María del Carmen Ruiz, Raquel Serrano, Jorge Pérez-Valle, Joaquin Ariño, Jose Ramos

Date Published: 3rd Jul 2009

Journal: FEBS Lett.

Abstract (Expand)

Recently, we showed that the MarR-type repressor YkvE (MhqR) regulates multiple dioxygenases/glyoxalases, oxidoreductases and the azoreductase encoding yvaB (azoR2) gene in response to thiol-specific ...

Authors: Montira Leelakriangsak, Nguyen Thi Thu Huyen, Stefanie Töwe, Nguyen van Duy, Dörte Becher, Michael Hecker, Haike Antelmann, Peter Zuber

Date Published: 16th Jan 2008

Journal: Mol. Microbiol.

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