Regulatory principles and experimental approaches to the circadian control of starch turnover


In many plants, starch is synthesized during the day and degraded during the night to avoid carbohydrate starvation in darkness. The circadian clock participates in a dynamic adjustment of starch turnover to changing environmental condition through unknown mechanisms. We used mathematical modelling to explore the possible scenarios for the control of starch turnover by the molecular components of the plant circadian clock. Several classes of plausible models were capable of describing the starch dynamics observed in a range of clock mutant plants and light conditions, including discriminating circadian protocols. Three example models of these classes are studied in detail, differing in several important ways. First, the clock components directly responsible for regulating starch degradation are different in each model. Second, the intermediate species in the pathway may play either an activating or inhibiting role on starch degradation. Third, the system may include a light-dependent interaction between the clock and downstream processes. Finally, the clock may be involved in the regulation of starch synthesis. We discuss the differences among the models' predictions for diel starch profiles and the properties of the circadian regulators. These suggest additional experiments to elucidate the pathway structure, avoid confounding results and identify the molecular components involved.


PubMed ID: 24335560

Projects: Millar group

Publication type: Not specified

Journal: J R Soc Interface

Citation: J R Soc Interface. 2013 Dec 11;11(91):20130979. doi: 10.1098/rsif.2013.0979. Print 2014 Feb 6.

Date Published: 18th Dec 2013

Registered Mode: Not specified

Authors: D. D. Seaton, O. Ebenhoh, A. J. Millar, A. Pokhilko

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Created: 6th Feb 2017 at 12:30

Last updated: 8th Dec 2022 at 17:26

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