Bert Poolman is professor in biochemistry and program director of the Centre for Synthetic Biology. His research focuses on the elucidation of the mechanisms by which signals are transduced and small molecules are translocated across cellular membranes. Cells are reengineered for the production of correctly folded membrane proteins, and methods are developed to reconstitute complex molecular assemblies in synthetic membranes and to analyze their functional and structural properties. The in vitro mechanistic studies are used to strengthen in vivo physiological measurements and vice versa. Research topics in his group include: (i) the mechanisms of translocation catalysis by ATP-binding cassette transporters; (ii) the molecular basis of cell volume regulation, incl. a comprehensive understanding of the role of lipid-protein interactions, (macro)molecular crowding and other generic physicochemical factors in transmembrane signaling and transport; and (iii) membrane proteomics with a focus on nuclear and vacuolar membranes and the basis for molecule transport through the nuclear pore complex.
SEEK ID: https://fairdomhub.org/people/38
Location:
Netherlands
ORCID: Not specified
Joined: 1st Apr 2009
Expertise: Biochemistry, Proteomics, membrane biology, protein-lipid interactions, physicochemical properties of membranes, functional protein expression
Tools: The Membrane Enzymology group focuses on the molecular mechanisms of transport and signalling across biological membranes. In other words: How do m..., engineering principles and approaches from molecular biology and synthetic chemistry are applied. Confocal microscopy and various spectroscopic met...
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SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".
The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.
Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...
Projects: BaCell-SysMO, COSMIC, SUMO, KOSMOBAC, SysMO-LAB, PSYSMO, SCaRAB, MOSES, TRANSLUCENT, STREAM, SulfoSys, SysMO DB, SysMO Funders, SilicoTryp, Noisy-Strep
Web page: http://sysmo.net/
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Public web page: http://www.sysmo.net/index.php?index=56
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