Investigations

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160 Investigations visible to you, out of a total of 458

Die Charité – Universitätsmedizin Berlin betreibt gemeinsam mit dem Berlin Institute of Health Clinical Study Center (BIH-CSC) eine zentrale Registerstudie ("Pa-COVID-19") und Phänotypisierungs- plattform für alle an der Charité behandelten Patienten mit COVID-19. Pa-COVID-19 dient der harmonisierten und standardisierten klinischen und molekularen Phänotypisierung von COVID-19 Patienten. Übergeordnetes Ziel ist die schnelle und umfassende Charakterisierung von COVID-19 zur Identifikation von ...

Submitter: Matthias Löbe

Studies: No Studies

Assays: No Assays

No description specified

Submitter: James Wordsworth

Studies: No Studies

Assays: No Assays

Multiply perturbations of trypanosome redox metabolism, closing the feedback loop between experimentation and in silioc modelling, allowing model refinement or, where there are unexpected outcomes, re-evaluation. Providing a dynamic picture of cell physiology by examining programmed metabolic changes during the developmental life-cycle of these parasites as they adapt to very different external milieus, including distinct levels of oxidative stress and unique adaptations of their redox balance ...

In this investigation, we aim to develop automatic workflows to pinpoint drug targets carrying genomic variants at high frequency in the population

No description specified

Present in many industrial effluents and as intermediate of lignin degradation, phenol is a widespread pollutant causing serious environmental problems, due to its toxicity to animals and humans. Removal of phenol from the environment by bacteria has been studied extensively over the past decades, but only little is known about phenol biodegradation in hostile environments. We combined metabolomics and transcriptomics together with metabolic modelling to elucidate the organism’s response to growth ...

The gluconeogenic conversion of 3-phosphoglycerate via 1,3-bisphosphoglycerate to glyceraldehyde-3-phosphate was compared at 30 C and at 70 C. At 30 C it was possible to produce 1,3-bisphosphoglycerate from 3-phosphoglycerate with phosphoglycerate kinase, but at 70 C, 1,3- bisphosphoglycerate was dephosphorylated rapidly to 3-phosphoglycerate, effectively turning the phosphoglycerate kinase into a futile cycle. At both temperatures it was possible to convert 3-phosphoglycerate to glyceraldehyde ...

Multiscale and multicellular simulation of SARS-CoV-2 infection uncover points of intervention to evade apoptosis.

Summary:

Our framework enables the simulation of the dynamics of signaling pathways that include the relevant players in SARS-CoV-2 infection, at the level of the individual cell and of the cell population. These different players encompass the virus, epithelial and immune cells. The model focuses on apoptosis and suggests two knock out alterations that force apoptosis of the ...

Experimental approaches to study the mechanism and ions involved in potassium uptake after long term potassium starvation.

Data, FMv2 model and simulations for the Chew et al. 2017 paper (bioRxiv https://doi.org/10.1101/105437 ), updated 2022 as bioRxiv https://doi.org/10.1101/105437v2, mostly on the prr7 prr9 double mutant, with controls in lsf1 and prr7 single mutants. This is one of the outputs from the EU TiMet project, https://fairdomhub.org/projects/92.

This data archive was updated during submisson to the journal _in Silico _Plants in 2022, and a Snapshot was published. NB ...

No description specified

Submitter: Beatriz García-Jiménez

Studies: No Studies

Assays: No Assays

No description specified
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