These Python scripts define and simulate the translational coincidence model. This model takes measured transcript dynamics (Blasing et al, 2005) in 12L:12D, measured synthesis rates of protein in light compared to dark (Pal et al, 2013), and outputs predicted changes in protein abundance between short (6h) and long (18h) photoperiods. These are compared to the photoperiod proteomics dataset we generated.
SEEK ID: https://fairdomhub.org/assays/593
Biological problem addressed: Model Analysis Type
Created: 4th Dec 2017 at 22:41
Last updated: 20th Feb 2018 at 23:03
EU FP7 collaborative project TiMet, award number 245143. Funded 2010-2015.
"TiMet assembles world leaders in experimental and theoretical plant systems biology to advance understanding of the regulatory interactions between the circadian clock and plant metabolism, and their emergent effects on whole-plant growth and productivity."
Click on Snapshot 2 to download data, models and analysis for Daniel Seaton et al.
biorXiv 2017 https://doi.org/10.1101/182071 and
Molecular Systems Biology, accepted Jan 2018, https://doi.org/10.15252/msb.20177962.
Note that the published paper cannot be fully linked into this record as the DOI above was not live when we made the Research Object from this Investigation on FAIRDOMHub.
Studies: Modelling and analysis of translational coincidence, Photoperiod-specific proteome data for Arabidopsis, Proteome and translation rate data for the Ostreococcus alga and for cya..., Rhythmic and photoperiod-specific transcriptome datasets for Arabidopsis
Assays: Aryal et al, 2011, metabolic labelling of Cyanothece protein synthesis, Blasing et al, 2005, diurnal microarray in 12L:12D, Estimation of rates of translation and turnover from proteomics datasets, Martin et al, 2012, Ostreococcus N15 labelling proteomics data, Photoperiod proteomics, Stitt lab, TiMet photoperiod microarrays, Translational coincidence model
Data analysis and modelling scripts and results for the Seaton et al. 2017 study, from Daniel Seaton.
Person responsible: Andrew Millar
Snapshots: No snapshots
Investigation: Photoperiodic control of the Arabidopsis proteo...
Assays: Translational coincidence model
Mean and standard deviation of protein abundances in 6h, 8h, 12h, and 18h photoperiods.
Creator: Daniel Seaton
Contributor: Daniel Seaton
Model type: Algebraic equations
Model format: Not specified
Environment: Not specified
Organism: Arabidopsis thaliana
Investigations: Photoperiodic control of the Arabidopsis proteo...
Modelling analyses: Translational coincidence model