Phenol degradation in Saccharolobus solfataricus P2
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Present in many industrial effluents and as intermediate of lignin degradation, phenol is a widespread pollutant causing serious environmental problems, due to its toxicity to animals and humans. Removal of phenol from the environment by bacteria has been studied extensively over the past decades, but only little is known about phenol biodegradation in hostile environments. We combined metabolomics and transcriptomics together with metabolic modelling to elucidate the organism’s response to growth with phenol as sole carbon source.
SEEK ID: https://fairdomhub.org/investigations/401
Projects: SulfoSys - Biotec
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Meina Neumann-Schaal, Jörn Kalinowski
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Created: 23rd Jul 2020 at 13:36
Last updated: 23rd Jul 2020 at 13:37
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Head of the group of Molecular Enzyme Technology and Biochemistry (Faculty of Chemistry) at the University of Duisburg-Essen. My research interest is on archaeal physiology with a special focuss on the central carbohydrate metabolism of (hyper)thermophilic Archaea and its regulation. The aim is to gain a systems level understanding by the combination of modern highthrouput analyses with classical biochemistry and molecular biology. Archaea possess many novel enzymes and pathways and our aim is ...
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Web page: http://www.fona.de/en/14276
Within the e:Bio - Innovationswettbewerb Systembiologie (Federal Ministry of Education and Research (BMBF)), the SulfoSYSBIOTECH consortium (10 partners), aim to unravel the complexity and regulation of the carbon metabolic network of the thermoacidophilic archaeon Sulfolobus solfataricus (optimal growth at 80°C and pH 3) in order to provide new catalysts ‘extremozymes’ for utilization in White Biotechnology.
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Programme: e:Bio
Public web page: http://www.sulfosys.com/
To investigate phenol degradation in Saccharolobus solfataricus transcriptome and metabolome analyses were performed with cells grown on phenol as sole carbon source. Cells grown on D-glucose served as reference. Metabolic modelling was used to compare efficiency of phenol utilization in terms of oxygen demand and energy yield with the reference condition.
Submitter: Jacqueline Wolf
Investigation: Phenol degradation in Saccharolobus solfataricu...
Assays: Metabolome analysis: phenol vs D-glucose, RNA Sequencing: phenol vs D-glucose
Submitter: Jacqueline Wolf
Assay type: Experimental Assay Type
Technology type: Gas Chromatography
Investigation: Phenol degradation in Saccharolobus solfataricu...
Submitter: Jacqueline Wolf
Assay type: Experimental Assay Type
Technology type: Rna-seq
Investigation: Phenol degradation in Saccharolobus solfataricu...
Creators: Andreas Albersmeier, Jörn Kalinowski
Submitter: Jacqueline Wolf
Creator: Jacqueline Wolf
Submitter: Jacqueline Wolf
