Pasquale Linciano

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About Pasquale Linciano:

No description specified

SEEK ID: https://fairdomhub.org/people/1966

Location: Italy

ORCID: Not specified

Joined: 26th Mar 2021

Expertise: Not specified

Tools: Not specified

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Related items

Advanced Programmes list for this Person with search and filtering

Drug development for neglected parasitic diseases

No description specified

Projects: NMTrypI - New Medicines for Trypanosomatidic Infections

Web page: https://cordis.europa.eu/programme/id/FP7_HEALTH.2013.2.3.4-2

Advanced Projects list for this Person with search and filtering

NMTrypI - New Medicines for Trypanosomatidic Infections

The New Medicines for Trypanosomatidic Infections - NMTrypI project aimed at obtaining new candidate drugs against Trypanosomatidic infections with appropriate efficiency from the lead phase to the final preclinical phase that are more accessible to patients.

Programme: Drug development for neglected parasitic diseases

Public web page: https://fp7-nmtrypi.eu/

Start date: 1st Feb 2014

End date: 31st Jan 2017

Organisms: Trypanosoma brucei, Leishmania donovani, Leishmania infantum, Leishmania major, Trypanosoma cruzi

Advanced Institutions list for this Person with search and filtering

Università degli Studi di Modena e Reggio Emilia (UNIMORE)

Country: Italy

City: Modena

Web page: https://www.unimore.it/

Advanced Investigations list for this Person with search and filtering

Phenotypic and machine learning approaches for hit to lead optimization of broad spectrum non-toxic antiparasitic agents

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Submitter: Pasquale Linciano

Studies: Chemical characterization, and biological evaluation of the SECONDARY HITS, Ty-Box chemical characterization, properties and biological evaluation

Assays: Antimicobacterium, Antiparasitic and in vitro toxicity for Ty-Box library, Biological characterization for Secondary Hits, Molecular Formula STRING excel, MolecularFormula Strings Spreadsheet_Ty, Secondary Hits Characterization, Ty-Box library characterization

Snapshots: No snapshots

Created: 26th Mar 2021 at 19:16

Advanced Studies list for this Person with search and filtering

Chemical characterization, and biological evaluation of the SECONDARY HITS

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Submitter: Pasquale Linciano

Investigation: Phenotypic and machine learning approaches for ...

Assays: Biological characterization for Secondary Hits, Molecular Formula STRING excel, Secondary Hits Characterization

Snapshots: No snapshots

Created: 26th Mar 2021 at 20:31, Last updated: 26th Mar 2021 at 20:31

Ty-Box chemical characterization, properties and biological evaluation

NMTrypI - New Medicines for Trypanosomatidic Infections

Chemical structures, physicochemical properties and biological results for the compounds of the Ty-Box library

Submitter: Pasquale Linciano

Investigation: Phenotypic and machine learning approaches for ...

Assays: Antimicobacterium, Antiparasitic and in vitro toxicity for Ty-Box library, MolecularFormula Strings Spreadsheet_Ty, Ty-Box library characterization

Snapshots: No snapshots

Created: 26th Mar 2021 at 19:20

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Ty-Box library characterization

NMTrypI - New Medicines for Trypanosomatidic Infections

Compound data and computational prediction of physicochemical properties

Submitter: Pasquale Linciano

Biological problem addressed: Chemical characterization

Investigation: Phenotypic and machine learning approaches for ...

Study: Ty-Box chemical characterization, properties an...

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: Predicted Physichcemical Properties for Ty-Box ..., SDF file of Ty-Box compounds, SMILES string for Ty-Box Library components

Snapshots: No snapshots

Created: 26th Mar 2021 at 19:25, Last updated: 26th Mar 2021 at 20:35

Antimicobacterium, Antiparasitic and in vitro toxicity for Ty-Box library

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Submitter: Pasquale Linciano

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Phenotypic and machine learning approaches for ...

Study: Ty-Box chemical characterization, properties an...

Organisms: No organisms

SOPs: No SOPs

Data files: Table S1a. Activity and toxicity profile of the..., Table S1b. In vitro early toxicity profiles (IC...

Snapshots: No snapshots

Created: 26th Mar 2021 at 19:56, Last updated: 17th May 2021 at 12:30

Secondary Hits Characterization

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Submitter: Pasquale Linciano

Biological problem addressed: Chemical characterization

Investigation: Phenotypic and machine learning approaches for ...

Study: Chemical characterization, and biological evalu...

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: NMR_spectra_of_the_secondary_hits, SDF file of Secondary Hits, SMILES string for Secondary Hits

Snapshots: No snapshots

Created: 26th Mar 2021 at 20:35, Last updated: 26th Mar 2021 at 20:50

Biological characterization for Secondary Hits

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Submitter: Pasquale Linciano

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Phenotypic and machine learning approaches for ...

Study: Chemical characterization, and biological evalu...

Organisms: No organisms

SOPs: No SOPs

Data files: Table S10. Predicted according to the elaborate..., Table S9. Predicted antiparasitic activity acco...

Snapshots: No snapshots

Created: 26th Mar 2021 at 20:42, Last updated: 26th Mar 2021 at 20:43

Molecular Formula STRING excel

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Submitter: Pasquale Linciano

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Phenotypic and machine learning approaches for ...

Study: Chemical characterization, and biological evalu...

Organisms: No organisms

SOPs: No SOPs

Data files: Molecular Formula STRING, Molecular Formula STRING

Snapshots: No snapshots

Created: 7th Oct 2023 at 16:57, Last updated: 7th Oct 2023 at 16:59

MolecularFormula Strings Spreadsheet_Ty

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Submitter: Pasquale Linciano

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Phenotypic and machine learning approaches for ...

Study: Ty-Box chemical characterization, properties an...

Organisms: No organisms

SOPs: No SOPs

Data files: Molecular Formula STRING

Snapshots: No snapshots

Created: 13th Oct 2023 at 07:12, Last updated: 13th Oct 2023 at 07:15

Advanced Data files list for this Person with search and filtering

MolecularFormula Strings Spreadsheet_Ty

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: No Investigations

Studies: No Studies

Assays: No Assays

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Created: 13th Oct 2023 at 07:16, Last updated: 13th Oct 2023 at 07:17

Molecular Formula STRING

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Chemical characterization, and biological evalu...

Assays: Molecular Formula STRING excel

Download

Created: 7th Oct 2023 at 16:59

Molecular Formula STRING

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Chemical characterization, and biological evalu...

Assays: Molecular Formula STRING excel

Download

Created: 7th Oct 2023 at 16:23

Molecular Formula STRING

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Ty-Box chemical characterization, properties an...

Assays: MolecularFormula Strings Spreadsheet_Ty

Created: 7th Oct 2023 at 16:23

SMILES string for Secondary Hits

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Chemical characterization, and biological evalu...

Assays: Secondary Hits Characterization

Download

Created: 26th Mar 2021 at 20:50, Last updated: 26th Mar 2021 at 20:51

SDF file of Secondary Hits

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Chemical characterization, and biological evalu...

Assays: Secondary Hits Characterization

Created: 26th Mar 2021 at 20:47, Last updated: 26th Mar 2021 at 20:47

Table S10. Predicted according to the elaborated Bayesian model vs. experimental early toxicity profile of the secondary hits.

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Chemical characterization, and biological evalu...

Assays: Biological characterization for Secondary Hits

Created: 26th Mar 2021 at 20:43

Table S9. Predicted antiparasitic activity according to the elaborated Bayesian model and experimental antiparasitic activity

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Chemical characterization, and biological evalu...

Assays: Biological characterization for Secondary Hits

Created: 26th Mar 2021 at 20:39

NMR_spectra_of_the_secondary_hits

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Chemical characterization, and biological evalu...

Assays: Secondary Hits Characterization

Created: 26th Mar 2021 at 20:33

Table S1b. In vitro early toxicity profiles (IC50 in μM) for the reference drugs

NMTrypI - New Medicines for Trypanosomatidic Infections

In vitro early toxicity profiles (all experiments were performed in triplicate, IC50 in μM) for the reference drugs Pentamidine (PEN), Benzidazole (BZD), Amphotericin B (AmB) and Miltefosine (MIL).

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Ty-Box chemical characterization, properties an...

Assays: Antimicobacterium, Antiparasitic and in vitro t...

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Created: 26th Mar 2021 at 20:13, Last updated: 26th Mar 2021 at 20:13

Table S1a. Activity and toxicity profile of the 456-training set of Ty-Box compounds

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Ty-Box chemical characterization, properties an...

Assays: Antimicobacterium, Antiparasitic and in vitro t...

Download

Created: 26th Mar 2021 at 20:01, Last updated: 26th Mar 2021 at 20:02

Predicted Physichcemical Properties for Ty-Box compounds

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Ty-Box chemical characterization, properties an...

Assays: Ty-Box library characterization

Created: 26th Mar 2021 at 19:49

SDF file of Ty-Box compounds

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Ty-Box chemical characterization, properties an...

Assays: Ty-Box library characterization

Download

Created: 26th Mar 2021 at 19:39

SMILES string for Ty-Box Library components

NMTrypI - New Medicines for Trypanosomatidic Infections

No description specified

Creator: Pasquale Linciano

Submitter: Pasquale Linciano

Investigations: Phenotypic and machine learning approaches for ...

Studies: Ty-Box chemical characterization, properties an...

Assays: Ty-Box library characterization

Download

Created: 26th Mar 2021 at 19:27

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