Phenotypic and machine learning approaches for hit to lead optimization of broad spectrum non-toxic antiparasitic agents
- Order Studies
Investigation position:
Export PNG
Views: 838
Created: 26th Mar 2021 at 19:16
This item has not yet been tagged.
Related items
Projects: NMTrypI - New Medicines for Trypanosomatidic Infections
Web page: https://cordis.europa.eu/programme/id/FP7_HEALTH.2013.2.3.4-2
The New Medicines for Trypanosomatidic Infections - NMTrypI project aimed at obtaining new candidate drugs against Trypanosomatidic infections with appropriate efficiency from the lead phase to the final preclinical phase that are more accessible to patients.
Programme: Drug development for neglected parasitic diseases
Public web page: https://fp7-nmtrypi.eu/
Start date: 1st Feb 2014
End date: 31st Jan 2017
Submitter: Pasquale Linciano
Investigation: Phenotypic and machine learning approaches for ...
Assays: Biological characterization for Secondary Hits, Molecular Formula STRING excel, Secondary Hits Characterization
Snapshots: No snapshots
Chemical structures, physicochemical properties and biological results for the compounds of the Ty-Box library
Submitter: Pasquale Linciano
Investigation: Phenotypic and machine learning approaches for ...
Assays: Antimicobacterium, Antiparasitic and in vitro toxicity for Ty-Box library, MolecularFormula Strings Spreadsheet_Ty, Ty-Box library characterization
Snapshots: No snapshots
Compound data and computational prediction of physicochemical properties
Submitter: Pasquale Linciano
Biological problem addressed: Chemical characterization
Investigation: Phenotypic and machine learning approaches for ...
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: Predicted Physichcemical Properties for Ty-Box ..., SDF file of Ty-Box compounds, SMILES string for Ty-Box Library components
Snapshots: No snapshots
Submitter: Pasquale Linciano
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Phenotypic and machine learning approaches for ...
Organisms: No organisms
SOPs: No SOPs
Data files: Table S1a. Activity and toxicity profile of the..., Table S1b. In vitro early toxicity profiles (IC...
Snapshots: No snapshots
Submitter: Pasquale Linciano
Biological problem addressed: Chemical characterization
Investigation: Phenotypic and machine learning approaches for ...
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: NMR_spectra_of_the_secondary_hits, SDF file of Secondary Hits, SMILES string for Secondary Hits
Snapshots: No snapshots
Submitter: Pasquale Linciano
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Phenotypic and machine learning approaches for ...
Organisms: No organisms
SOPs: No SOPs
Data files: Table S10. Predicted according to the elaborate..., Table S9. Predicted antiparasitic activity acco...
Snapshots: No snapshots
Submitter: Pasquale Linciano
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Phenotypic and machine learning approaches for ...
Organisms: No organisms
SOPs: No SOPs
Data files: Molecular Formula STRING, Molecular Formula STRING
Snapshots: No snapshots
Submitter: Pasquale Linciano
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Phenotypic and machine learning approaches for ...
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Investigations: Phenotypic and machine learning approaches for ...
Studies: Chemical characterization, and biological evalu...
Assays: Molecular Formula STRING excel
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Investigations: Phenotypic and machine learning approaches for ...
Studies: Chemical characterization, and biological evalu...
Assays: Molecular Formula STRING excel
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Investigations: Phenotypic and machine learning approaches for ...
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Investigations: Phenotypic and machine learning approaches for ...
Studies: Chemical characterization, and biological evalu...
Assays: Secondary Hits Characterization
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Investigations: Phenotypic and machine learning approaches for ...
Studies: Chemical characterization, and biological evalu...
Assays: Secondary Hits Characterization
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Investigations: Phenotypic and machine learning approaches for ...
Studies: Chemical characterization, and biological evalu...
Assays: Secondary Hits Characterization
In vitro early toxicity profiles (all experiments were performed in triplicate, IC50 in μM) for the reference drugs Pentamidine (PEN), Benzidazole (BZD), Amphotericin B (AmB) and Miltefosine (MIL).
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Investigations: Phenotypic and machine learning approaches for ...
Studies: Ty-Box chemical characterization, properties an...
Assays: Ty-Box library characterization
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Investigations: Phenotypic and machine learning approaches for ...
Studies: Ty-Box chemical characterization, properties an...
Assays: Ty-Box library characterization
Creator: Pasquale Linciano
Submitter: Pasquale Linciano
Investigations: Phenotypic and machine learning approaches for ...
Studies: Ty-Box chemical characterization, properties an...
Assays: Ty-Box library characterization