Pharmacogenomics of drugs targeting the COVID-19 disease map
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In this study, we developed a workflow to compute a modified version of the Cumulative Allele Probability (CAP) for genes in the COVID-19 disease map and the “Drug Risk Probability” (DRP) score for drugs targeting genes in the map (Schärfe et al., 2017). The CAP score considers the number of pharmacogenomic variants and their frequency in the population for a specific gene. The DRP score combines the CAP scores for all drug target genes for a specific drug. For this, we use allelic frequencies from GNOMAD exome data and pharmacogenomics information from PharmGKB. The analyses are implemented in R, and available at https://github.com/jpinero/pharmacogenomics_covid19_minerva_map
SEEK ID: https://fairdomhub.org/studies/838
Pharmacogenomics data analysis workflow
Projects: COVID-19 Disease Map
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Created: 14th Apr 2021 at 07:29
Last updated: 14th Apr 2021 at 09:12
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Projects: COVID-19 Disease Map
Institutions: Hospital del Mar Research Institute (IMIM)
https://orcid.org/0000-0002-9383-528X
Projects: COVID-19 Disease Map
Institutions: Hospital del Mar Research Institute (IMIM)
https://orcid.org/0000-0003-1244-7654
Postdoctoral Researcher
The Disease Maps Project is designed as a large-scale community effort. It is a network of groups that work together in order to better understand disease mechanisms. The project exchanges best practices, share information, develop tools to make it easier for all the involved groups to achieve their goals.
Projects: COVID-19 Disease Map
Web page: https://disease-maps.org
Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.
Programme: Disease Maps
Public web page: http://doi.org/10.17881/covid19-disease-map
In this investigation, we aim to develop automatic workflows to pinpoint drug targets carrying genomic variants at high frequency in the population
Submitter: Janet Piñero
Studies: Pharmacogenomics of drugs targeting the COVID-19 disease map
Assays: No Assays
