Pharmacogenomics of drugs targeting the COVID-19 disease map

In this study, we developed a workflow to compute a modified version of the Cumulative Allele Probability (CAP) for genes in the COVID-19 disease map and the “Drug Risk Probability” (DRP) score for drugs targeting genes in the map (Schärfe et al., 2017). The CAP score considers the number of pharmacogenomic variants and their frequency in the population for a specific gene. The DRP score combines the CAP scores for all drug target genes for a specific drug. For this, we use allelic frequencies from GNOMAD exome data and pharmacogenomics information from PharmGKB. The analyses are implemented in R, and available at https://github.com/jpinero/pharmacogenomicscovid19minerva_map

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Created: 14th Apr 2021 at 09:29

Last updated: 14th Apr 2021 at 11:12

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