People

I'm a PhD student at the lab of Prof. Dr. Jörg Stülke. My main interest is to analyze the central metabolism of Bacillus subtilis using systems biology software. I have developed an algorithm to find short pathways connecting sets of metabolites and I'm also involved in SubtiWiki, the wiki for all genes of Bacillus subtilis (http://subtiwiki.uni-goettingen.de)

Optimisation of Bacillus subtilis for the secretion of heterologous proteins Therapeutic proteins (including those required for experimental purposes and clinical trials) are major products of biomanufacturing processes and considerable time and expense are expended to maximise the yield and quality of proteins produced in heterologous hosts. The production host of choice is the Gram-negative bacterium Escherichia coli for which many strains and expression systems have been developed. However, ...

CURRICULUM VITAE

Wolfgang Hillen Full Professor and Chairman of Microbiology Lehrstuhl für Mikrobiologie Institut für Biologie Friedrich-Alexander Universität Erlangen-Nürnberg Staudtstr. 5 91058 Erlangen, Fed. Rep. of Germany

Date of Birth: April 24, 1948 Place of Birth: Osnabrück, FRG Nationality: German Status: Married Children: Hauke Sven Hillen - May 17, 1987

RESEARCH AND PROFESSIONAL EXPERIENCE

Present Full Professor and Chairman of Microbiology at the Institute of Biology, Friedrich-Alexander ...

I am a biologist in the lab of Prof. Reuss at the University of Stuttgart and I am working in the field of biotechnology and mathematical modelling.

Group leader Molecular Genetics

The main component of research in my group is in the determination of macromolecular structures by X-ray crystallography. However, since not all proteins crystallize, every effort is made to complete our understanding of how proteins function by utilizing other methods, such as microbial genetics, monitoring protein:ligand interactions by biochemical and biophysical methods, electron microscopy and bioinformatics

Modelling of the general stress response activation cascade of sigB in B. subtilis in response to starvation.

I'm Post-Doc in the lab of Prof. Becher at the University of Greifswald. I'm working on the relative and absolute protein quantitation using gel-based and mass-spectrometric methods.

PhD student. Analyzing CcpA affinity to cre boxes (catabolite responsive elements) and response of B. subtilis to membrane protein overproduction stress.

Modelling of cellular signalling, Dynamic Motifs and Feedback, Quantitative Measures, Theoretical Aspects of Modelling Biological Systems

I am pursuing my PhD at Prof. Volker's Lab in the Department of Functional Genomics, EMA Universitat Greifswald, Germany. I am working on the general stress responses mediated by SigB and the prediction of SigB regulon members using the Random forest algorithm.

I am a postdoc in the lab of Rick Lewis working on the biophysical characterization of protein-protein complexes involved in central carbon metabolism.

Professor for Biochemcial Engineering, University Stuttgart

I am PhD student at Prof.Uwe Voelker lab in Department of Functional Genomics. My area of research is microbial functional genomics in particular analysing the whole transcriptome(by microarray and other molecular biolology methods) of B.subtilis under various stress conditions. I use QconCAT strategy for absolute quantification of carbon metabolic enzymes via MRM(multiple reaction monitoring) by LC-MS/MS. I also perofrm experiments for understanding of dynamics of SigmaB network for modelling.

I studied chemistry in Erlangen and started research on carbon catabolite regulation in Bacillus megaterium in my diploma thesis. During my PhD thesis I was concerned with quantitative analyses of protein-protein and protein-DNA interactions of CcpA, in vivo- and in vitro-characterization of point mutants of CcpA and coeffectors and I contributed to the structural analysis of different CcpA complexes. During a postdoctoral appointment I focused on interaction analyses of PrfA, a regulator of ...

I started to work with B. subtilis during my diploma thesis in Marburg, analyzing the gene expression pattern during sporulation and their control by the four sporulation sigma factors. This work was continued during my PhD thesis in Greifswald. In collaboration with Prof. Bremer and Prof. Marahiel in Marburg we also studied additional adaptation processes of B. subtilis, like the adaptation to low temperatur and high osmolarity. I am now working as a staff scientist in Prof. Völkers lab in ...