Projects: WG2 - Integration of early phase studies and low environmental impact actions, WG6 - Promote the transfer of knowledge, WG5 - Promote dissemination, WG1 - Compound libraries coordination and integration of compound design
Institutions: Università degli Studi di Sienahttps://orcid.org/0000-0003-2574-3911
Expertise: structural biology, Cancer research, parassite research, drug development, antibiotic resistance, drug resistance, antibacterial drugs, neurodegenerative diseases, metalloproteins, protein-protein interactions, protein production
Tools: Biochemistry and protein analysis, Spectroscopy and structural analysis, rtPCR, fluorescence spectroscopy, quantitative western blot analysis, Molecular biology techniques (RNA/DNA), Fluorescence and confocal microscopy FRAP/FLIP
The focus of our research is the protein biogenesis and how stress-related factors modulate it. Protein biogenesis in general comprises various processes, i.e., translation, protein folding, each of which responds differently to external stress stimuli. Using systems biology approaches we seek to understand the interplay between these processes in fine-tuning the protein pattern and proteins’ abundance under osmotic stress conditions.
Tools: Genetics, Proteomics, Pharmacology and toxicology, Spectroscopy and structural analysis, Web services, PCR, Fluorescence and confocal microscopy, quantitative Western analyses), molecular biological techniques (RNA/DNA techniques, Proteomics (2D-PAGE), quantitative western blot analyses, Molecular biology techniques (RNA/DNA), transcriptional analysis (Northern blots
Postdoctoral Research fellow with experience in Genomics, transcriptomics, proteomics and metabolomics
Work in my laboratory is focussed on microbial physiology - the study of how bacteria and other microorganisms work. Although rooted in the tradition of bacterial growth and intermediary metabolism, microbial physiology now embraces molecular biology, genetics, biochemistry, and indeed any discipline that can shed light on bacterial function. Much of our experimental work is conducted with Escherichia coli, the pre-eminent ‘model’ organism with unrivalled ease of genetic and physiological ...
I am a postdoc in the lab of Rick Lewis working on the biophysical characterization of protein-protein complexes involved in central carbon metabolism.