Matthias Reuss

Overview
Related items

About Matthias Reuss:

Professor for Biochemcial Engineering, University Stuttgart

SEEK ID: https://fairdomhub.org/people/141

Location: Germany

ORCID: Not specified

Joined: 12th May 2009

Expertise: Reactor models, rapid sampling experiments, Systems Biology, Mathematical modeling, Regulatory Networks, Dynamics and Control of Biological Networks

Tools: Fermentation, stimulus response experiments, evaluation of process dynamics, continuous cultivation, Computational Systems Biology, including:- Dynamic modelling- Parameter estimation- Optimal experimental design- Dynamic optimization, Dynamic modelling, In silico Metabolic Network Analysis, fed-batch cultivation

Their tags

This person has not yet tagged anything.

Related items

Advanced Programmes list for this Person with search and filtering

SysMO

SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".

The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.

Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...

Projects: BaCell-SysMO, COSMIC, SUMO, KOSMOBAC, SysMO-LAB, PSYSMO, SCaRAB, MOSES, TRANSLUCENT, STREAM, SulfoSys, SysMO DB, SysMO Funders, SilicoTryp, Noisy-Strep

Web page: http://sysmo.net/

Advanced Projects list for this Person with search and filtering

BaCell-SysMO

BaCell-SysMO 2 Modelling carbon core metabolism in Bacillus subtilis – Exploring the contribution of protein complexes in core carbon and nitrogen metabolism.

Bacillus subtilis is a prime model organism for systems biology approaches because it is one of the most advanced models for functional genomics. Furthermore, comprehensive information on cell and molecular biology, physiology and genetics is available and the European Bacillus community (BACELL) has a well-established reputation for applying ...

Programme: SysMO

Public web page: http://www.sysmo.net/index.php?index=53

Organisms: Bacillus subtilis

COSMIC

Systems Biology of Clostridium acetobutylicum - a possible answer to dwindling crude oil reserves

Programme: SysMO

Public web page: http://www.sysmo.net/index.php?index=54

Organisms: Clostridium acetobutylicum

PSYSMO

Systems analysis of process-induced stresses: towards a quantum increase in process performance of Pseudomonas putida as the cell factory of choice for white biotechnology.

The specific goal of this project is to exploit the full biotechnological efficacy of Pseudomonas putida KT2440 by developing new optimization strategies that increase its performance through a systems biology understanding of key metabolic and regulatory parameters that control callular responses to key stresses generated ...

Programme: SysMO

Public web page: http://www.psysmo.org/

Organisms: Pseudomonas putida

MOSES

MOSES (Micro Organism Systems biology: Energy and Saccharomyces cerevisiae) develops a new Systems Biology approach, which is called 'domino systems biology'. It uses this to unravel the role of cellular free energy ('ATP') in the control and regulation of cell function. MOSES operates though continuous iterations between partner groups through a new systems-biology driven data-management workflow. MOSES also tries to serve as a substrate for three or more other SYSMO programs.

Programme: SysMO

Public web page: http://www.moses.sys-bio.net/

Organisms: Saccharomyces cerevisiae

Advanced Institutions list for this Person with search and filtering

University of Stuttgart

Country: Germany

City: Stuttgart

Web page: http://www.uni-stuttgart.de

Advanced Publications list for this Person with search and filtering

Cell size and morphological properties of yeast Saccharomyces cerevisiae in relation to growth temperature

MOSES

Abstract (Expand)

Cell volume is an important parameter for modelling cellular processes. Temperature-induced variability of cellular size, volume, intracellular granularity, a fraction of budding cells of yeast …

Authors: Maksim Zakhartsev, Matthias Reuss

Date Published: 26th Apr 2018

Publication Type: Not specified

DOI: 10.1093/femsyr/foy052

Citation: Cell size and morphological properties of yeast Saccharomyces cerevisiae in relation to growth temperature 18(6) : 603

Created: 12th Jul 2018 at 19:12, Last updated: 8th Dec 2022 at 17:26

Metabolic efficiency in yeast Saccharomyces cerevisiae in relation to temperature dependent growth and biomass yield

MOSES

Abstract (Expand)

Canonized view on temperature effects on growth rate of microorganisms is based on assumption of protein denaturation, which is not confirmed experimentally so far. We develop an alternative concept, … which is based on view that limits of thermal tolerance are based on imbalance of cellular energy allocation. Therefore, we investigated growth suppression of yeast Saccharomyces cerevisiae in the supraoptimal temperature range (30–40 °C), i.e. above optimal temperature (Topt). The maximal specific growth rate (μmax) of biomass, its concentration and yield on glucose (Yx/glc) were measured across the whole thermal window (5–40 °C) of the yeast in batch anaerobic growth on glucose. Specific rate of glucose consumption, specific rate of glucose consumption for maintenance (mglc), true biomass yield on glucose (View the MathML source), fractional conservation of substrate carbon in product and ATP yield on glucose (Yatp/glc) were estimated from the experimental data. There was a negative linear relationship between ATP, ADP and AMP concentrations and specific growth rate at any growth conditions, whilst the energy charge was always high (~0.83). There were two temperature regions where mglc differed 12-fold, which points to the existence of a ‘low’ (within 5–31 °C) and a ‘high’ (within 33–40 °C) metabolic mode regarding maintenance requirements. The rise from the low to high mode occurred at 31–32 °C in step-wise manner and it was accompanied with onset of suppression of μmax. High mglc at supraoptimal temperatures indicates a significant reduction of scope for growth, due to high maintenance cost. Analysis of temperature dependencies of product formation efficiency and Yatp/glc revealed that the efficiency of energy metabolism approaches its lower limit at 26–31 °C. This limit is reflected in the predetermined combination of View the MathML source, elemental biomass composition and degree of reduction of the growth substrate. Approaching the limit implies a reduction of the safety margin of metabolic efficiency. We hypothesize that a temperature increase above Topt (e.g. >31 °C) triggers both an increment in mglc and suppression of μmax, which together contribute to an upshift of Yatp/glc from the lower limit and thus compensate for the loss of the safety margin. This trade-off allows adding 10 more degrees to Topt and extends the thermal window up to 40 °C, sustaining survival and reproduction in supraoptimal temperatures. Deeper understanding of the limits of thermal tolerance can be practically exploited in biotechnological applications.

Authors: Maksim Zakhartsev, Xuelian Yang, Matthias Reuss, Hans Otto Pörtner

Date Published: 1st Aug 2015

Publication Type: Not specified

DOI: 10.1016/j.jtherbio.2015.05.008

Citation: Journal of Thermal Biology 52 : 117

Created: 1st Nov 2015 at 17:35, Last updated: 8th Dec 2022 at 17:26

Fast sampling for quantitative microbial metabolomics: new aspects on cold methanol quenching: metabolite co-precipitation

MOSES

Abstract (Expand)

The intra- and extracellular concentrations of 16 metabolites were measured in chemostat (D = 0.1 h−1) anaerobic cultures of the yeast Saccharomyces cerevisiae CEN.PK-113-7D growing on minimal medium. …

Authors: Maksim Zakhartsev, Oliver Vielhauer, Thomas Horn, Xuelian Yang, Matthias Reuss

Date Published: 1st Apr 2015

Publication Type: Not specified

DOI: 10.1007/s11306-014-0700-8

Citation: Metabolomics 11(2) : 286

Created: 1st Nov 2015 at 17:50, Last updated: 8th Dec 2022 at 17:26

Simplified absolute metabolite quantification by gas chromatography–isotope dilution mass spectrometry on the basis of commercially available source material

MOSES

Abstract (Expand)

In the field of metabolomics, GC–MS has rather established itself as a tool for semi-quantitative strategies like metabolic fingerprinting or metabolic profiling. Absolute quantification of intra- or …

Authors: Oliver Vielhauer, , Thomas Horn, Ralf Takors,

Date Published: 1st Dec 2011

Publication Type: Not specified

DOI: 10.1016/j.jchromb.2011.10.036

Citation:

Created: 1st Mar 2012 at 11:04, Last updated: 8th Dec 2022 at 17:26

Integrated Sampling Procedure for Metabolome Analysis

COSMIC

Abstract

Not specified

Authors: Jochen Schaub, Carola Schiesling, , Michael Dauner

Date Published: 2006

Publication Type: Not specified

DOI: 10.1021/bp050381q

Citation:

Created: 26th Apr 2012 at 15:32, Last updated: 8th Dec 2022 at 17:26