Professor for Biochemcial Engineering, University Stuttgart
SEEK ID: https://fairdomhub.org/people/141
Tools: fed-batch cultivation, In silico Metabolic Network Analysis, Dynamic modelling, including:- Dynamic modelling- Parameter estimation- Optimal experimental design- Dynamic optimization, Computational Systems Biology, evaluation of process dynamics, continuous cultivation, stimulus response experiments, Fermentation
ORCID: Not specified
Systems analysis of process-induced stresses: towards a quantum increase in process performance of Pseudomonas putida as the cell factory of choice for white biotechnology.
The specific goal of this project is to exploit the full biotechnological efficacy of Pseudomonas putida KT2440 by developing new optimization strategies that increase its performance through a systems biology understanding of key metabolic and regulatory parameters that control callular responses to key stresses generated
MOSES (Micro Organism Systems biology: Energy and Saccharomyces cerevisiae) develops a new Systems Biology approach, which is called 'domino systems biology'. It uses this to unravel the role of cellular free energy ('ATP') in the control and regulation of cell function. MOSES operates though continuous iterations between partner groups through a new systems-biology driven data-management workflow. MOSES also tries to serve as a substrate for three or more other SYSMO programs.
Modelling carbon core metabolism in Bacillus subtilis – Exploring the contribution of protein complexes in core carbon and nitrogen metabolism.
Bacillus subtilis is a prime model organism for systems biology approaches because it is one of the most advanced models for functional genomics. Furthermore, comprehensive information on cell and molecular biology, physiology and genetics is available and the European Bacillus community (BACELL) has a well-established reputation for applying
Date Published: 26th Apr 2018
Journal: Not specified
Citation: Cell size and morphological properties of yeast Saccharomyces cerevisiae in relation to growth temperature 18(6) : 603
Date Published: 1st Apr 2015
Citation: Metabolomics 11(2) : 286
Date Published: 1st Aug 2015
Journal: Journal of Thermal Biology
Citation: Journal of Thermal Biology 52 : 117
Date Published: 1st Sep 2012
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Date Published: 1st Dec 2011
Journal: Journal of Chromatography B