The major theme of the research in my laboratory is bacterial gene regulation. We are interested in signal perception mechanisms (in particular oxygen); signal transduction (ligand induced protein confromational changes); interaction of transcription factors with the core transcription machinery; interactions between transcription factors to integrate multiple signals; and the influence of promoter architectures on these events. We are also interested in aome aspects of post-transcriptional
Expertise: quantative biology, Cell physiology, regulation of gene expression, Microbiology/ Protein chemistry/ Molecular Biology, Protein-DNA-interaction, Bacterial Cell Biology, carbon metabolism, bacterial metabolism, functional protein expression, Bacillus subtilis
Tools: surface plasmon resonance spectroscopy, reporter gene analysis, DNA, Molecular biology techniques (RNA/DNA/Protein), Chromatography, Model organisms, Cell biology, Biochemistry and protein analysis, Microbiology
Expertise: Clostridium, carbon metabolism, bacterial metabolism, Metabolic Engineering, Anaerobic Microbiology, Synthetic Biology, Clostridial Genetics, Systems Biology, Molecular Biology, Genetics, Microbiology
I'm an experimentalist 'Pre-doc' (I still have to finish my PhD thesis) and my work on the COSMIC project will focus on setting up a metabolomic analysis method for Clostridium acetobutylicum.
In the past I have worked on metabolic engineering of the same organism by disrupting genes to asses their impact on acid and solvent formation.
I'm looking forward to joining the COSMIC web-community. It hopefully will all us to stay in touch and update each other on advances in the (computer)lab.