Tools: Biochemistry and protein analysis, Bioinformatics, Systems Biology, SBML, R, ODE, Molecular biology techniques (RNA/DNA/Protein), Genetics, Dynamic modelling, Computational and theoretical biology, CellDesigner, Parameter estimation
Institutions: Leibniz Institute for Farm Animal Biology (FBN)https://orcid.org/0000-0002-7968-3152
Institutions: Rostock University Medical Centrehttps://orcid.org/0000-0001-6287-4916
Projects: Not specified
Institutions: Not specifiedhttps://orcid.org/0000-0003-2852-6648
I am performing research in biomarkers discovery, particularly regarding liver fibrosis in non-alcoholic fatty liver disease. My research activities involved the use of bioinformatic platforms, the analysis of biological protein-protein interaction networks and the experimental validation of candidates by ELISA.
Prof. Dr. Kathrin Thedieck
Leader WP8 – Project Coordination
I am an emeritus professor in Biochemistry at the University of Amsterdam (retired 2010).
My research focussed on the human chromatin in its natural environment, i.e. the nucleus of cultured living human cells.
Aspects, such as the dynamic folding of the chromatin fiber inside the nucleus and local chemical modification of histones and DNA at genetic loci, are the physical and chemical basis for epigenetic regulation of gene expression. In my group we worked parallel on human
Institutions: University of Tokyo
I am a postdoc in The University of Tokyo. My research interest is to know structure of biological systems by functional relationships between genes working in response to endogenous and/or exogenous disruptions. I'm trying to find functional relationships between genes by similarity of phenotype defined with high-dimensional morphological features in yeast gene deletion collection. I'm happy if you will talk with me in any topics.
Institutions: Åbo Akademi University
Tools: Molecular Biology, Cell biology, Computational and theoretical biology, Metabolomics, Model organisms, SBML, ODE, Partial differential equations, Algebraic equations, Linear equations, Copasi, JWS Online, Matlab, Mathematica, SQL, Material balance based modeling
I'm a modeller, specialized in kinetic modeling of biochemical networks. My focus in the SysMO-LAB consortium is on creating models of Lactococcus lactis glycolysis and couple this to other related lactic acid bacteria like Streptococcus pyogenes and Enterococcus faecalis. Besides kinetic modeling, I'm also interested in combining various modeling techniques (genome-scale modeling, qualitative modeling).
Tools: Microbiology, Molecular Biology, Biochemistry and protein analysis, Cell biology, Genetic analysis, Genomics, Transcriptomics, Proteomics, Model organisms, Proteomics (2D-PAGE), gene regulation, DNA technology RNA technology Protein analysis Fermentation Mutagenesis, molecular biological techniques (RNA/DNA techniques), protein interaction studies
Optimisation of Bacillus subtilis for the secretion of heterologous proteins Therapeutic proteins (including those required for experimental purposes and clinical trials) are major products of biomanufacturing processes and considerable time and expense are expended to maximise the yield and quality of proteins produced in heterologous hosts. The production host of choice is the Gram-negative bacterium Escherichia coli for which many strains and expression systems have been developed. However,
Expertise: Bacillus subtilis, functional protein expression, bacterial metabolism, carbon metabolism, Bacterial Cell Biology, Protein-DNA-interaction, Microbiology/ Protein chemistry/ Molecular Biology, Cell physiology, regulation of gene expression, quantative biology
Tools: Microbiology, Biochemistry and protein analysis, Cell biology, Model organisms, Chromatography, Molecular biology techniques (RNA/DNA/Protein), DNA, surface plasmon resonance spectroscopy, reporter gene analysis