Projects: COMBINE Multicellular Modellinghttps://orcid.org/0000-0002-7692-7203
Prof. Dr. Kathrin Thedieck
Leader WP8 – Project Coordination
I am a biotechnologist with main focus on theoretical studies. Currently, I am working on the implementation of a parameter estimation algorithm on GPUs to reduce the computational burden of huge ODE systems.
I am a PAL and I am looking forward to communication with other SYSMO members.
Institutions: Imperial College London
I am a PhD student in the Theoretical Systems Biology group, based at Imperial College London.
The aim of my PhD is to understand how noise can be the driving force of decision-making processes (differentiation, self-renewal, apoptosis or tumorgenesis), and what are our chances to control them. So far I have been working on method development for stochastic models, a moment closure framework and a stochastic reachability method, to look into cell-to-cell-variability.
Projects: Not specified
Institutions: Not specifiedhttps://orcid.org/0000-0002-4790-7377
Expertise: Mathematical modelling, Statistically and biologically inspired optimization algorithms, Mathematical modelling of biosystems and bioprocesses, Dynamics and Control of Biological Networks, Parameter estimation
Tools: Computational and theoretical biology, ODE, Partial differential equations, Matlab, Mathematica, Computational Systems Biology, including: - Dynamic modelling - Parameter estimation - Optimal experimental design - Dynamic optimization
We are very interested in applying a systems approach (i.e. model-based concepts and related computational tools) to problems from the biological domain. In particular, we are doing research in computational systems biology, targetting the following topics:
- Parameter estimation (inverse problems, model calibration) in biochemical pathways
- Optimal experimental design (optimal dynamic experiments) for Systems Biology
- Dynamic optimization (optimal control) of biosystems and bioprocesses
Expertise: Mathematical modelling of biosystems and bioprocesses, Optimal experimental design, Systems Biology, sensitivity analysis, Dynamic optimization., Dynamics and Control of Biological Networks, Parameter estimation
I am a postdoctoral researcher in the group of Julio Banga. My research is focused on computational systems biology with particular attention to the mathematical modelling of biosystems and bioprocesses. Some of the topics we address are:
- Parameter estimation
- Model identifiability
- Global sensitivity analysis
- Optimal experimental design
- Dynamic optimization
- Robust control of diffusion-reaction systems
Expertise: Mathematical modelling, Bacillus subtilis, Deterministic modelling of gene regulation networks, stress responses, Systems Biology, sensitivity analysis, Dynamics and Control of Biological Networks, Parameter estimation
Modelling of the general stress response activation cascade of sigB in B. subtilis in response to starvation.
Tools: Computational and theoretical biology, ODE, Matlab, Mathematica, differential algebraic equations, Stochastic models, C programming, Computational Systems Biology, Dynamic modelling, Data Modelling
Modelling of cellular signalling, Dynamic Motifs and Feedback, Quantitative Measures, Theoretical Aspects of Modelling Biological Systems
Tools: Fermentation, stimulus response experiments, evaluation of process dynamics, continuous cultivation, Computational Systems Biology, including:- Dynamic modelling- Parameter estimation- Optimal experimental design- Dynamic optimization, Dynamic modelling, In silico Metabolic Network Analysis, fed-batch cultivation
Professor for Biochemcial Engineering, University Stuttgart
Roles: Vice Coordinator
Expertise: Metabolic Pathway Analysis and Engineering Microbial Physiology Modeling of Biological Networks Industrial Systems Biotechnology White Biotech..., genome-scale modeling, enzyme kinetics, Dynamics and Control of Biological Networks
Since August 2008 I am professor in Systems Biology at the VU University Amsterdam. My Systems Bioinformatics group focusses on systems biology with a special focus on integrative bioinformatics. It aims at forming bridges between the classical bottom-up approaches in systems biology and the more data-driven approaches in classical bioinformatics. We combine experimental, modeling and theoretical approaches to study cellular physiology, with an emphasis on metabolic networks.
Expertise: Biochemistry, coupling metabolome and environome, rapid sampling experiments, Systems Biology, carbon metabolism, Stoichiometric modelling, Proteomics, Metabolomics, yeast, fungi, Dynamics and Control of Biological Networks
Tools: Biochemistry and protein analysis, Metabolomics, Matlab, Fermentation, Chromatography, Material balance based modeling, stimulus response experiments, continuous cultivation, Enzyme assay, Mass spectrometry (LC-MS/MS), HPLC, GC and LC/MS analysis of metabolites, ODE, Parameter estimation
I've become a SysMO DB PAL for MOSES project in 2007 being a post-doc in lab of Prof. Matthias Reuss at University of Stuttgart. In the MOSES project, our major efforts were in the experimental data acquisition for dynamic model of primary carbon and anaerobic energy metabolism in yeast. The model implements prediction of perturbations of two types: glucose pulse and temperature jump. We implement “stimulus-response” methodology for the unraveling the dynamic structure of the network and to
Expertise: Molecular Biology, Bioinformatics, Mathematical modelling, Reactor models, dynamics of biological networks, Mathematical and statistical modeling, bioreactor models, Dynamics and Control of Biological Networks, Parameter estimation
Tools: Bioinformatics, Computational and theoretical biology, Transcriptomics, Model organisms, Single Cell analysis, SBML, ODE, Linear equations, Matlab, Microarray analysis, linux, Material balance based modeling, stimulus response experiments, DIVA, differential algebraic equations, evaluation of process dynamics, continuous cultivation
I'm an engineer at the MPI Magdeburg and I'm working in the field of mathematical modeling, model verification, parameter identification, model analysis and experimental design. I'm involved in two projects, KOsmoBac and PSYSMO.
Institutions: University of Rostock
Tools: Computational and theoretical biology, ODE, Matlab, Mathematica, stimulus response experiments, differential algebraic equations, quantitative western blot analyses, quantitative western blot analysis, Stochastic models