Projects
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Programme: This Project is not associated with a Programme
Public web page: Not specified
This is the FAIRDOM hub for the Make Me My Model part of ISBE.NL. Various models for ISDBE.NL clients are stored here.
Programme: Innate immunity
Public web page: http://isbe.nl/
Programme: Independent Projects
Public web page: Not specified
Understanding the molecular basis of diseases can shed light into new methods to manage and cure diseases. Exploring the common or unique molecular mechanisms among a group of diseases may enhance our understanding of each disease or uncover therapeutic approaches that can be effective in multiple diseases. In this project we develop methods that use biological networks and known gene-disease associations to identify common molecular mechanisms associated across multiple diseases.
Programme: Cancer drug discovery preclinical research
Public web page: Not specified
Programme: Independent Projects
Public web page: Not specified
Programme: Mathematical modelling of the morphological transition of Pseudomonas aeruginosa
Public web page: Not specified
Programme: Independent Projects
Public web page: Not specified
This research discusses what is the status of fisheries provisioning services in Jatigede Reservoir and what anthropogenic pressures in the form of community activities affect the status of fisheries provisioning services.
Programme: Independent Projects
Public web page: Not specified
Using standard systems biology methodologies a 14-compartment dynamic model was developed for the Corona virus epidemic. The model predicts that: (i) it will be impossible to limit lockdown intensity such that sufficient herd immunity develops for this epidemic to die down, (ii) the death toll from the SARS-CoV-2 virus decreases very strongly with increasing intensity of the lockdown, but (iii) the duration of the epidemic increases at first with that intensity and then decreases again, such that ...
Programme: Model repository for M4 (Make Me My Model) clients of ISBE
Public web page: Not specified
Start date: 1st Mar 2020
End date: 24th Mar 2023
MESI-Review 2024
Programme: Independent Projects
Public web page: Not specified
MESI-STRAT: Systems Medicine of Metabolic-Signaling Networks -A New Concept for Breast Cancer Patient Stratification. Breast cancer is a complex disease with high prevalence in the European Union and world-wide. 75%-80 of the patients have estrogen receptor-positive (ER)-positive tumors and are treated with endocrine therapies. Endocrine therapies, which block ER-driven tumor growth, show high efficacy. Yet, a significant proportion of the patients will eventually relapse with metastatic breast ...
Programme: This Project is not associated with a Programme
Public web page: http://www.mesi-strat.eu
MESI-STRAT Review
Programme: Independent Projects
Public web page: Not specified
Systems biology of bacterial methylotrophy for biotechnological
Programme: ERASysAPP
Public web page: http://www.sintef.no/projectweb/metapp/
Programme: Metastasis Network
Public web page: Not specified
experimental data; middle ear transfer functions
Programme: Independent Projects
Public web page: https://www.ercd.net
Andrew Millar's research group, University of Edinburgh
Programme: SynthSys
Public web page: http://www.amillar.org
This project aims to characterise the mechanisms through which microRNAs and small non-coding RNAs act to regulate cellular processes focusing on Naïve CD4 T cell activation and viral replication - namely HIV - and to explore their potential use as a therapeutic co-adjuvant agents or targets.
Programme: MIT Superfund Research
Public web page: Not specified
The main idea of MIX-UP (MIXed plastics biodegradation and UPcycling using microbial communities) is to showcase a novel approach for plastic recycling and therefore addresses one of the greatest challenges of our time: the establishment of a circular (bio)-economy for plastics. The continuing demand for plastic products, the lack of appropriate recycling and the ubiquitous pollution of the environment with plastic waste pose a global challenge. An ambitious vision and considerable efforts are ...
Programme: de.NBI Systems Biology Service Center (de.NBI-SysBio)
Public web page: https://www.mix-up.eu/
Time series response of potato cv. Désirée, which is tolerant to PVY infection, was analysed in both inoculated as well as upper non-inoculated leaves. Additionally, transgenic plants deficient in accumulation of salicylic acid (NahG- Désirée) were studied in the same setting.
This investigation is published under the CC BY 4.0 license.
Programme: NIBSys
Public web page: Not specified
Modulation of light, temperature and time networks using prime editing and mathematical modelling
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Programme: COMBINE (Computational Modeling in Biology Network)
Public web page: Not specified
Modelling COVID-19 epidemics : the training course organized by ISBE-NL, ELIXIR-LU, and EOSC-Life
Programme: Independent Projects
Public web page: https://elixir-luxembourg.org/events/2020_11_30_COVID19_modelling_training
Start date: 30th Nov 2020
End date: 31st Jan 2021
tba
Programme: iPlacenta: A European Union Horizon 2020 innovative training network (ITN)
Public web page: Not specified
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
The Molecular Systems Biology project holds information for reproducing simulation figures in the journal. This can include experimental data files, model files and manuscript information.
Programme: Journals
Public web page: http://msb.embopress.org
MOSES (Micro Organism Systems biology: Energy and Saccharomyces cerevisiae) develops a new Systems Biology approach, which is called 'domino systems biology'. It uses this to unravel the role of cellular free energy ('ATP') in the control and regulation of cell function. MOSES operates though continuous iterations between partner groups through a new systems-biology driven data-management workflow. MOSES also tries to serve as a substrate for three or more other SYSMO programs.
Programme: SysMO
Public web page: http://www.moses.sys-bio.net/
Programme: de.NBI Systems Biology Service Center (de.NBI-SysBio)
Public web page: Not specified
Valorization of mussel processing water into bioplastics
Programme: Independent Projects
Public web page: Not specified
Programme: Independent Projects
Public web page: Not specified
We will contribute to the LiSyM Research Network an open source, freely available and reproducible multiscale model of the human liver from single cell metabolism to whole liver function. The model will be available in existing standards of systems biology, provide standardized interfaces for data integration and be fully annotated to available biological, medical and computational ontologies. All data, models and source code will be shared within the LiSyM Research Network and made available to ...
Programme: LiSyM - Systems Medicine of the Liver
Public web page: https://livermetabolism.com
BBSRC sLoLa grantThe spread of antimicrobial resistance (AMR) is a slow-moving pandemic that has been identified by the WHO as one of the top 10 threats facing humanity. Plasmids and other MGEs play a key role in the dissemination of AMR, but we have only a rudimentary understanding of the factors that determine if and how MGEs spread through microbial communities. It is generally assumed that bacterial immune systems are a major determinant, but existing studies are limited to only a few stand-alone ...
Programme: MultiDefence - sLoLa
Public web page: Not specified
Short-chain fatty-acids (SCFA) are produced from dietary fibres by the intestinal microbiota. They protect humans against obesity. The fate of SCFA and their impact on human fat metabolism is complex and dynamic. To optimally apply prebiotic (fibre) and probiotic (microbial) supplements, a better understanding of their mode of action is required. Our aim is to construct, infer, and analyse a dynamic, multiscale computational model predicting how dietary fibres affect the balance between fat intake ...
Programme: Independent Projects
Public web page: https://www.nwo.nl/en/research-and-results/research-projects/i/75/29175.html
The MycoSynVac project AIMS at using cutting-edge synthetic biology methodologies to engineer Mycoplasma pneumoniae as a universal chassis for vaccination. Designing a universal Mycoplasma chassis that can be deployed as single- or multi-vaccine in a range of animal hosts. Annually, infections caused by Mycoplasma species in poultry, cows, and pigs result in multimillion Euro losses in the USA and Europe. There is no effective vaccination against many Mycoplasmas that infect pets, humans and farm ...
Programme: Independent Projects
Public web page: http://www.mycosynvac.eu/