MicroRNAs are a recently discovered group of factors that control cell behaviour. There are thousands of microRNAs, but specific ones control the behaviour of cartilage cells and have key roles in osteoarthritis. Changing the level of a single microRNA can alter osteoarthritis, but we know that several microRNAs change during disease. The group has identified four microRNAs which have key roles in cartilage. This programme seeks:

to show that these microRNAs have a role in osteoarthritis in the

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