40 samples, OE mutants of glycolysis and pyruvate metabolism enzymes combined with metabolite levels of all 40 samples

Simulation of OE mutants targetting enzymes in the model, combined with metabolite concentrations and enzyme fold change of from the 40 samples. For each second mutant the enzyme concentrations in case of OE and KO mutants in updated and the metabolite concentrations of the second sample are loaded in the model. Using this approach the model approximately predicts combinatorial effects of OE mutations with other mutations, perturbations and time series concentrations.

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Created: 1st May 2017 at 12:21

Last updated: 20th Nov 2019 at 00:19

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