P6: MRI assessment of liver function, perfusion and fat distribution

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Within the overarching goal of the research unit QuaLiPerF to gain a data-integrated, multi-scale understanding of the interplay between hepatic perfusion and function and its recovery after extended hepatectomy (ePHx), this subproject (P6) is devoted to experimental MRI investigations in rats. This subproject aims to establish a comprehensive MR imaging toolbox for small animal imaging at 9.4T and to provide MRI-based spatially resolved, multi-parametric quantitative in vivo information on liver size, function, and perfusion under various experimental conditions. More specifically, in this project, MRI examinations are performed on rats before and after portal vein ligation (PVL) and partial hepatectomy, and animals are monitored longitudinally during regeneration. In addition, the effects of a fat diet on the different MRI parameters, used to characterize the liver status, will also be investigated longitudinally. These data serve to monitor adaptations after PVL and the regenerative response of the remnant liver after ePHx and – together with complementary experimental and clinical data from the subprojects P1, P2, P4, and P9 of the research unit – form an important source of information for comparison of the predicted temporal changes provided by the mathematical models of the subprojects P3, P7 and P8 on the organ scale. Subproject P6 will also be in exchange with subproject P5, which aims to integrate the data into models on different scales based on statistical approaches. Upon completion of the first funding period of the research unit, a substantial body of experimental in vivo data will be available, which together with the iterative computational modeling and data integration will allow a better prediction of the recovery of liver function.

SEEK ID: https://fairdomhub.org/investigations/770

Projects: Quantifizierung des Zusammenhanges zwischen Leberperfusion und -funktion...

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