Projects that do not fall under current programmes.

Komplexe, erweiterte Leberresektionen ((e)PHx) stellen ein hohes Risiko für ein postoperatives Leberversagen dar, insbesondere bei einer bereits bestehenden Lebererkrankung. Das Ziel von QuaLiPerF ist es, bisher unbekannte Wechselwirkungen zwischen den durch die Operation verursachten Veränderungen der Perfusion und der Stoffwechselfunktion aufzuklären. Wir werden einen systemmedizinischen Ansatz anwenden, um ein mehrskaliges Modell der Leberperfusion und -funktion zu erstellen, das die Vorhersage ...

Patients subjected to extended liver resection ((e)PHx) have a high risk to experience postoperative liver dysfunction or even liver failure, especially in case of preexisting liver disease. Our research group QuaLiPerF aims to enhance the understanding of the quantitative and spatial relationship between hepatic perfusion and function in healthy, steatotic and regenerating livers after surgery using a systems medicine approach. This project will focus on assessing the impact of perfusion ...

Within the overarching goal of the research unit QuaLiPerF to gain a data-integrated, multi-scale understanding of the interplay between hepatic perfusion and function and its recovery after extended hepatectomy (ePHx), this subproject (P6) is devoted to experimental MRI investigations in rats. This subproject aims to establish a comprehensive MR imaging toolbox for small animal imaging at 9.4T and to provide MRI-based spatially resolved, multi-parametric quantitative in vivo information on liver ...

todo ...

Fat quantification of 5 liver lobes (RML, LML, LLL, RL, CL) During the MRI sesssion at least one PRESS voxel was placed in each of those liver lobes to acquire PRESS data for later fat analysis. Acquisitions were without water suppression, so the fat peaks are relatively small.

The quantification was performed using lcmodel. The original MRI data are part of the MRI session assays (data files uploaded). Here you can find the additional analysis and the output of lcmodel: The "ps" in each exam ...

animals underwent a 60% PVL surgery and this MRI session was performed on post operation day 5 (POD5).

Complete original MRI data for POD5. Bruker format but human readable link names as exam folder, so instead of 2/ the folder is named E002_Anatomy_Light_T2_E2/ derived from the display name.

Perfusion Analysis of Control group

The MRI Perfusion technique is FAIR, so three maps were calulated:

Selective Inversion T1 Map Global inversion T1 map Perfusion Map (ml/min/100g)

This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.

The** original Perfusion Map from the Bruker scanner** are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder pdata/ 1/ ...

PRESS based fat quantification

Fat quantification of 5 liver lobes (RML, LML, LLL, RL, CL) During the MRI sesssion at least one PRESS voxel was placed in each of those liver lobes to acquire PRESS data for later fat analysis. Acquisitions were without water suppression, so the fat peaks are relatively small.

The quantification was performed using lcmodel. The original MRI data are part of the MRI session assays (data files uploaded). Here you can find the additional analysis and the output of ...

The animals undergoing 60% PVL surgery. Surgeries were all performed in room E040a, WKFZ in the S1 area "Kleintier MRT". Post surgery holding was in room E040c directly next door and the final MRI in room E040a and room E040b.

All surgeries were performed by the same surgeon, Wei Weiwei from Prof. Dahmens group (P2).

The Control group underwent no surgery whatsoever (no sham). For the 4 groups POD1, 2, 3 and 5 MRI was performed on the respective day after surgery.

rat samples for POD5 group.

generic sample type "rat" with attribute for strain.