Patients subjected to extended liver resection ((e)PHx) have a high risk to experience postoperative liver dysfunction or even liver failure, especially in case of preexisting liver disease. Our research group QuaLiPerF aims to enhance the understanding of the quantitative and spatial relationship between hepatic perfusion and function in healthy, steatotic and regenerating livers after surgery using a systems medicine approach. This project will focus on assessing the impact of perfusion ...
Within the overarching goal of the research unit QuaLiPerF to gain a data-integrated, multi-scale understanding of the interplay between hepatic perfusion and function and its recovery after extended hepatectomy (ePHx), this subproject (P6) is devoted to experimental MRI investigations in rats. This subproject aims to establish a comprehensive MR imaging toolbox for small animal imaging at 9.4T and to provide MRI-based spatially resolved, multi-parametric quantitative in vivo information on liver ...
Submitter: Karl-Heinz Herrmann
Studies: Control Group, In vivo fat quantification with MRS (PRESS), PVL POD1 Group, PVL POD2 Group, PVL POD3 Group, PVL POD5 Group
Assays: Fat quantification using MR PRESS data, MRI Session Control Group, MRI Session POD1, MRI Session POD2, MRI Session POD3, MRI Session POD5, Perfusion Analysis (Bruker & MATLAB) - Control Group, Perfusion Analysis (Bruker & MATLAB) - POD1 Group, Perfusion Analysis (Bruker & MATLAB) - POD2 Group, Perfusion Analysis (Bruker & MATLAB) - POD3 Group, Perfusion Analysis (Bruker & MATLAB) - POD5 Group
animals underwent a 60% PVL surgery and this MRI session was performed on post operation day 1 (POD1).
Submitter: Karl-Heinz Herrmann
Investigation: P6: MRI assessment of liver function, perfusion...
Assays: MRI Session POD1, Perfusion Analysis (Bruker & MATLAB) - POD1 Group
Perfusion Analysis of Control group
The MRI Perfusion technique is FAIR, so three maps were calulated:
Selective Inversion T1 Map Global inversion T1 map Perfusion Map (ml/min/100g)
This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.
The** original Perfusion Map from the Bruker scanner** are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder pdata/ 1/ ...
Submitter: Karl-Heinz Herrmann
Assay type: Image Analysis
Technology type: Imaging
Investigation: P6: MRI assessment of liver function, perfusion...
Study: PVL POD1 Group
Perfusion Analysis of Control group
The MRI Perfusion technique is FAIR, so three maps were calulated:
- Selective Inversion T1 Map
- Global inversion T1 map
- Perfusion Map (ml/min/100g)
This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.
The original Perfusion Map from the Bruker scanner are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder ...
Submitter: Karl-Heinz Herrmann
Biological problem addressed: Tissue Perfusion
Investigation: P6: MRI assessment of liver function, perfusion...
Study: Control Group
