This version is derived from a model from the article: Extension of a genetic network model by iterative experimentation and mathematical analysis. Locke JC, Southern MM, Kozma-Bognár L, Hibberd V, Brown PE, Turner MS, Millar AJ Mol. Syst. Biol. 2005; 1: 2005.0013 16729048, SBML model of the interlocked feedback loop network The model describes the circuit depicted in Fig. 4 and reproduces the simulations in Figure 5A and 5B. It provides initial conditions, parameter values and rules for the production rates of the following species: LHY mRNA (cLm), cytoplasmic LHY (cLc), nuclear LHY (cLn), TOC1 mRNA (cTm), cytoplasmic TOC1 (cTc), nuclear TOC1 (cTn),X mRNA (cXm), cytoplasmic X (cXc), nuclear X (cXn), Y mRNA (cYm), cytoplasmic Y (cYc), nuclear Y (cYn), nuclear P (cPn). Compared to the original version in Biomodels database, BIOMD0000000055.xml.origin, this version uses a better description of the light-dark cycle, by Drs. Ozgur Akman and Kevin Stratford. The model contains a candidate for a community-standard cyclic function, which uses tanh functions to achieve rapid yet numerically continuous steps from light to darkness, rather than discrete events in SBML.
Locke J.C.W., Southern M.M., Kozma-Bognar L., Hibberd V., Brown P.E., Turner M.S., Millar A.J. (2005). Extension of a genetic network model by iterative experimentation and mathematical analysis.. Mol. Syst. Biol.. Retrieved from: http://www.nature.com/msb/journal/v1/n1/full/msb4100018.html
Originally submitted to PLaSMo on 2010-05-05 14:54:28
Created: 10th Jan 2019 at 17:38