This model is termed P2011 and derives from the article: <strong>The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops</strong><strong>. </strong>Alexandra Pokhilko, Aurora Piñas Fernández, Kieron D Edwards, Megan M Southern, Karen J Halliday & Andrew J Millar <em>Mol. Syst. Biol. </em>2012; 8: 574, submitted 9 Aug 2011 and published 6 March 2012. <a href="http://www.nature.com/msb/journal/v8/n1/synopsis/msb20126.html">Link</a> Link to <a href="http://www.nature.com/msb/journal/v8/n1/extref/msb20126-s1.pdf">Supplementary Information</a>, including equations. Minor errors in the published Supplementary Information are described in a file attached to version 1 of this model (the published SBML is correct). The model describes the circuit depicted in Fig. 1 of the paper (GIF attached). It updates the Pokhilko et al. 2010 model (termed P2010), <a href="http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_6">PLM_6</a>, by including:<ol>
Alexandra Pokhilko, Aurora Piñas Fernández, Kieron D Edwards, Megan M Southern, Karen J Halliday & Andrew J Millar (2012). The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops.. Mol. Syst. Biol. 8: 574.. Retrieved from: http://www.nature.com/msb/journal/v8/n1/synopsis/msb20126.html
Version 2 of the model includes the StepFunction. Note that we have not yet removed the original light function parameter names, they are now non-functional.2012-06-01 17:29:46 3 amillar2 firstname.lastname@example.org
The SBML for this version uses the StepFunction (as in Adams et al. J. Biol Rhythms 2012) to represent the light-dark cycle. It has parameter name Lightstep, ID step1. Parameter name L, which is used in the model reactions, is assigned the value of Lightstep.
Note version 3 has a Copasi file attached.
Originally submitted to PLaSMo on 2012-03-07 12:15:12
SEEK ID: https://fairdomhub.org/assays/841
Investigation: Millar, Andrew (ex-PlaSMo models)
Biological problem addressed: Gene Regulatory Network
Organisms: No organisms
Created: 10th Jan 2019 at 17:40
Last updated: 22nd Jan 2019 at 18:17