R-Script for integrative clusteranalysis of single cell and single nuclei data Version 1
This file contains the R-script to analyse single nuclei and single cell data of Bl6 and Fzt:DU mice previously processed with cellranger. The analyses utilizes the Seurat and harmony package to integrate three datasets before subsequent downstream analysis characterizing proliferative cardiomyocytes.
SEEK ID: https://fairdomhub.org/sops/429?version=1
Filename:
proliferative cardiomyocytes.R
Format: Binary file
Size: 18.5 KB
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Views: 221 Downloads: 29
Created: 18th Mar 2020 at 16:01
Last updated: 19th Mar 2020 at 10:53
Last used: 19th Sep 2020 at 05:12
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Related items
https://orcid.org/0000-0002-7968-3152
The project addresses the generation and establishment of programmed pacemaker cells for an in vitro drug testing possibility to perform predictive tests. This may lead to an improved treatment of cardiac arrhythmias or an accurate identification of potential drug molecules at a very early stage of development. Important benefits will arise in verifying the safety of a wide variety of medicines while reducing animal testing.
This project is funded by the European Social Fund (ESF) program of the
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Programme: Independent Projects
Public web page: Not specified
This study includes the single snRNA-seq in whole adult murine hearts from an inbred (C57BL/6NRj) and an outbred (Fzt:DU) mouse strain in comparison to publicly available scRNA-seq data of the tabula muris project.
Submitter: Anne-Marie Galow
Biological problem addressed: Model Analysis Type
Snapshots: No snapshots
