Validation of lactate flux inhibition by glucose transport inhibitor Version 2
SEEK ID: https://fairdomhub.org/models/177?version=2
1 item is associated with this Model:-
LACfluxValidation_Inhibition-SEEK.nb (Mathematica Notebook - 152 KB)
Organism: Plasmodium falciparum
Model type: Ordinary differential equations (ODE)
Model format: Mathematica
Execution or visualisation environment: Not specified
Model image: No image specified
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Contributor and Creators
Views: 3318 Downloads: 97
Created: 2nd Jul 2015 at 12:40
Last updated: 23rd Nov 2015 at 14:09
Last used: 16th Oct 2019 at 15:33
AttributionsNone
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Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, School of Computer Science, University of Manchester, Stellenbosch University
https://orcid.org/0000-0003-2633-0537
Hypoglycaemia and lactic acidosis are key diagnostics for poor chances of survival in malaria patients. In this project we aim to test to what extent the metabolic activity of Plasmodium falciparum contributes to a changed glucose metabolism in malaria patients. The approach is to start with detailed bottom up models for the parasite and then merge these with more coarse grained models at the whole body level.
Programme: SARCHI: Mechanistic modelling of health and epidemiology
Public web page: Not specified
The investigation entails the construction and validation of a detailed mathematical model for glycolysis of the malaria parasite Plasmodium falciparum in the blood stage trophozoite form.
Snapshots: Snapshot 1
Inhibition of lactate flux due to glucose transport inhibitor
Contributor: Dawie Van Niekerk
Biological problem addressed: Model Analysis Type
Snapshots: No snapshots
