Glucose metabolism in Plasmodium falciparum infected erythrocytes

The investigation entails the construction and validation of a detailed mathematical model for glycolysis erythrocytes infected with the malaria parasite Plasmodium falciparum in the blood stage form.

DOI: 10.15490/fairdomhub.1.investigation.604.1

Zenodo URL: None

Created at: 18th Aug 2023 at 09:14

Contents

Validation of model for malaria-infected erythrocytes

This study includes the experimental data for model validation and the model predictions of that data set.

GLC incubation

SED-ML: https://jjj.bio.vu.nl/models/experiments/vanniekerk2023_fig4/simulate

5 mM GLC runout data

No description specified

  • Validation-timecourse-dutoit2.xlsx

Kinetic model for incubation (dutoit2)

No description specified

  • dutoit2.xml

GLC incubation timecourses

No description specified

  • GLCincubation_dutoit2_timecourses.nb

Steady-state

No description specified

Stage specific fluxes

No description specified

  • Validation-stageFluxes.xlsx

Kinetic model for steady state (dutoit1)

No description specified

  • dutoit1.xml

Steady state (trophozoite stage)

No description specified

  • SteadyStateModel_dutoit1.nb

Flux vs parasitaemia

No description specified

Flux vs parasitaemia

No description specified

  • Validation-fluxPar-dutoit3.xlsx

Flux vs parasitaemia

No description specified

  • FluxVSparasitemia_dutoit3.nb

Flux vs external glucose

No description specified

Flux vs glucose

No description specified

  • Validation-fluxGlc-dutoit3.xlsx

Flux vs glucose

No description specified

  • FluxVSglc_dutoit3.nb

Stage specific fluxes

No description specified

Stage specific fluxes

No description specified

  • Validation-stageFluxes.xlsx

Stage specific fluxes

No description specified

  • StageFluxes_dutoit1.nb

Kinetic model for steady state (dutoit1)

No description specified

  • dutoit1.xml

Analysis of model for malaria-infected erythrocytes

This study includes the experimental data for model validation and the model predictions of that data set.

Inhibition of glycolytic flux

Inhibition of lactate flux glycolytic inhibitors

Lactate flux inhibition data

No description specified

  • Validation-LacFluxInhibition-vanniekerk1.xlsx

Glycolytic flux inhibition data (erythrocytes)

No description specified

  • Validation-GlycFluxInhibition-dutoit1.xlsx

Kinetic model for steady state (dutoit1)

No description specified

  • dutoit1.xml

Inhibition of glycolytic flux by glucose transport inhibitor (iRBC)

No description specified

  • CytInh-dutoit1.nb

Validation of lactate flux inhibition by glucose transport inhibitor

No description specified

  • LACfluxValidation_Inhibition-SEEK.nb

Glycolytic target analysis in malaria infected erythrocytes

No description specified

  • TargetAnalysis-dutoit1.nb

Metabolic control analysis

No description specified

Kinetic model for steady state (dutoit1)

No description specified

  • dutoit1.xml

MCA

No description specified

  • CC_dutoit1.nb

Intra-erythrocytic malaria parasite volumes

No description specified

Malaria parasite volume determinations

Determinations of parasite volumes in a well-synchronised, infected culture treated with a cytosolic stain, using fluorescence microscopy. Diameters used to calculate parasite volume, assuming a spherical parasite cell.

Malaria parasite volumes determined using microscopy

Volumes in fL, time in hours.

  • ParasiteVolumes.csv

Analysis of malaria parasite volumes per stage

No description specified

  • parasiteVolumeDetermination.nb
Fingerprints

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MD5: 84d7c3f786c175605aefe280d3b0511a

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Citation
Snoep, J., & Van Niekerk, D. (2023). Glucose metabolism in Plasmodium falciparum infected erythrocytes. FAIRDOMHub. https://doi.org/10.15490/FAIRDOMHUB.1.INVESTIGATION.604.1
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Snapshot 1 (18th Aug 2023) DOI
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Created: 18th Aug 2023 at 09:14

Last updated: 18th Aug 2023 at 09:15

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