Model analysis
SEEK ID: https://fairdomhub.org/studies/138
Glucose metabolism in Plasmodium falciparum trophozoites
Projects: Whole body modelling of glucose metabolism in malaria patients
Experimentalists: Not specified
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Created: 1st Jul 2015 at 10:14
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orcid.org/0000-0003-2633-0537
Hypoglycaemia and lactic acidosis are key diagnostics for poor chances of survival in malaria patients. In this project we aim to test to what extent the metabolic activity of Plasmodium falciparum contributes to a changed glucose metabolism in malaria patients. The approach is to start with detailed bottom up models for the parasite and then merge these with more coarse grained models at the whole body level.
Programme: SARCHI: Mechanistic modelling of health and epidemiology
Public web page: Not specified
The investigation entails the construction and validation of a detailed mathematical model for glycolysis of the malaria parasite Plasmodium falciparum in the blood stage trophozoite form.
Snapshots: Snapshot 1
Contributor: Dawie Van Niekerk
Biological problem addressed: Model Analysis Type
Snapshots: No snapshots
Inhibition of lactate flux due to glucose transport inhibitor
Contributor: Dawie Van Niekerk
Biological problem addressed: Model Analysis Type
Snapshots: No snapshots
Contributor: Dawie Van Niekerk
Biological problem addressed: Model Analysis Type
Snapshots: No snapshots
Creators: Dawie Van Niekerk, Jacky Snoep
Contributor: Dawie Van Niekerk
Model type: Ordinary differential equations (ODE)
Model format: Mathematica
Environment: Not specified
Creators: Dawie Van Niekerk, Jacky Snoep
Contributor: Dawie Van Niekerk
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: Not specified
Creators: Dawie Van Niekerk, Jacky Snoep
Contributor: Dawie Van Niekerk
Model type: Ordinary differential equations (ODE)
Model format: Mathematica
Environment: Not specified
Creators: Dawie Van Niekerk, Jacky Snoep
Contributor: Dawie Van Niekerk
Model type: Ordinary differential equations (ODE)
Model format: Mathematica
Environment: Not specified
Glycolytic model for Plasmodium falciparum; open system
Creators: Dawie Van Niekerk, Jacky Snoep
Contributor: Dawie Van Niekerk
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: JWS Online
Abstract (Expand)
Authors: Dawie Van Niekerk, Jacky Snoep, Penkler Gerald,du Toit Francois,Adams Waldo,Rautenbach Marina,Palm Daniel C.
Date Published: 1st Apr 2015
Journal: FEBS J
Abstract (Expand)
Authors: Dawie Van Niekerk, Jacky Snoep, Penkler Gerald P.,du Toit Francois
Date Published: 1st Feb 2016
Journal: FEBS J
