FIGURE 5: The deletion of the β1-β2 loop does not alter the geometry of the active site and yet, abolishes the effect of ATP on NAMPT activity
SEEK ID: https://fairdomhub.org/assays/1143
Experimental Assay
Projects: NAMPT affinity
Investigation: hidden item
Study: Manuscript: structural determinants of substrate binding to NAMPT
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Assay type: Experimental Assay Type
Technology type: Technology Type
Organisms: No organisms
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Created: 22nd Oct 2019 at 17:57
Last updated: 13th Nov 2019 at 17:08
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Projects: NAMPT affinity, NAD phylogeny
Institutions: University of Bergen
Projects that do not fall under current programmes.
Projects: Manchester Institute for Biotechnology, ICYSB 2015 - International Practical Course in Systems Biology, iRhythmics, INBioPharm, EmPowerPutida, Systo models, MycoSynVac - Engineering Mycoplasma pneumoniae as a broad-spectrum animal vaccine, Multiscale modelling of state transitions in the host-microbiome-brain network, Extremophiles metabolsim, NAD COMPARTMENTATION, Agro-ecological modelling, Bergen(Ziegler lab) project AF-NADase, NAMPT affinity, Stress granules, Modelling COVID-19 epidemics, Bio-crop, ORHIZON, Coastal Data, SASKit: Senescence-Associated Systems diagnostics Kit for cancer and stroke, hybrid sequencing, HOST-PAR, BioCreative VII, Boolean modeling of Parkinson disease map, Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish, Selective Destruction in Ageing, Viral Metagenomic, Synthetic biology in Synechococcus for bioeconomy applications (SynEco), testproject, SDBV ephemeral data exchanges, Test project, The BeeProject, PHENET, LiceVault, EbN1 Systems Biology
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Submitter: Dorothee Houry
Investigation: 1 hidden item
Assays: FIGURE 2: Crystal structures of human NAMPT in complex with NA and PRPP,..., FIGURE 3: ATP is essential for NAMN formation by NAMPT, FIGURE 4: ATP indirectly stabilizes PRPP via pHis247., FIGURE 5: The deletion of the β1-β2 loop does not alter the geometry of ..., FIGURE 6: SAXS analysis of WT and Δ42-51 NAMPT.
Burgos, E. S., Ho, M. C., Almo, S. C., and Schramm, V. L. (2009) A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proceedings of the National Academy of Sciences of the United States of America 106, 13748-13753
Creator: Dorothee Houry
Submitter: Dorothee Houry
Creator: Dorothee Houry
Submitter: Dorothee Houry
