Manuscript: structural determinants of substrate binding to NAMPT
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DOI: 10.15490/fairdomhub.1.study.666.1
Zenodo URL: None
Created at: 13th Nov 2019 at 16:08
FIGURE 2: Crystal structures of human NAMPT in complex with NA and PRPP, or NAMN
No description specified
PDB ID 3DHD
Burgos, E. S., Ho, M. C., Almo, S. C., and Schramm, V. L. (2009) A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proceedings of the National Academy of Sciences of the United States of America 106, 13748-13753
- 3dhd.pdb
FIGURE 3: ATP is essential for NAMN formation by NAMPT
No description specified
Fig3: NAMN formation w/ and w/o ATP in WT NAMPT
No description specified
- Fig3_NAMN formation in WT NAMPT.xlsx
FIGURE 5: The deletion of the β1-β2 loop does not alter the geometry of the active site and yet, abolishes the effect of ATP on NAMPT activity
No description specified
NMN and NAMN formation w/ and w/o ATP in Δ42-51 NAMPT
No description specified
- Fig4_NAMN-NMN formation in Δ42-51 NAMPT.xlsx
PDB ID 3DHF
Burgos, E. S., Ho, M. C., Almo, S. C., and Schramm, V. L. (2009) A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proceedings of the National Academy of Sciences of the United States of America 106, 13748-13753
- 3dhf.pdb
FIGURE 6: SAXS analysis of WT and Δ42-51 NAMPT.
No description specified
SAXS raw data of WT and Δ42-51 NAMPT w/ Nam, NA, PRPP or as apoenzyme
No description specified
- Fig5_SAXS_rawdata_22102019.xlsx
FIGURE 4: ATP indirectly stabilizes PRPP via pHis247.
No description specified
PDB ID 3DHD
Burgos, E. S., Ho, M. C., Almo, S. C., and Schramm, V. L. (2009) A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proceedings of the National Academy of Sciences of the United States of America 106, 13748-13753
- 3dkj.pdb
PDB ID 3DKF
Burgos, E. S., Ho, M. C., Almo, S. C., and Schramm, V. L. (2009) A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proceedings of the National Academy of Sciences of the United States of America 106, 13748-13753
- 3dkf.pdb
PDB ID 3DKL
Burgos, E. S., Ho, M. C., Almo, S. C., and Schramm, V. L. (2009) A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proceedings of the National Academy of Sciences of the United States of America 106, 13748-13753
- 3dkl.pdb
PDB ID 2E5C
Takahashi, R., Nakamura, S., Nakazawa, T., Minoura, K., Yoshida, T., Nishi, Y., Kobayashi, Y., and Ohkubo, T. (2010) Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase. J Biochem 147, 95-107
- 2e5c.pdb
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Created: 13th Nov 2019 at 16:08
Last updated: 13th Nov 2019 at 16:12
