People

Modelling of the general stress response activation cascade of sigB in B. subtilis in response to starvation.

Modelling of cellular signalling, Dynamic Motifs and Feedback, Quantitative Measures, Theoretical Aspects of Modelling Biological Systems

I am PhD student at Prof.Uwe Voelker lab in Department of Functional Genomics. My area of research is microbial functional genomics in particular analysing the whole transcriptome(by microarray and other molecular biolology methods) of B.subtilis under various stress conditions. I use QconCAT strategy for absolute quantification of carbon metabolic enzymes via MRM(multiple reaction monitoring) by LC-MS/MS. I also perofrm experiments for understanding of dynamics of SigmaB network for modelling.

I started to work with B. subtilis during my diploma thesis in Marburg, analyzing the gene expression pattern during sporulation and their control by the four sporulation sigma factors. This work was continued during my PhD thesis in Greifswald. In collaboration with Prof. Bremer and Prof. Marahiel in Marburg we also studied additional adaptation processes of B. subtilis, like the adaptation to low temperatur and high osmolarity. I am now working as a staff scientist in Prof. Völkers lab in ...

By training I am a molecular microbiologist with a particular interest in bacterial stress adaptation reactions. Since the early 90ies we have used functional genomics technologies, particularly proteomics, to investigate the response of Bacillus subtilis to environmental challenges. I am currently Head of the Functional Genomics Department of the Interfaculty Institute of Genetics and Functional Genomics at the Ernst-Moritz-Arndt-University Greifswald. Within the Department we are applying ...

www.sbi.uni-rostock.de/wolkenhauer