Figure 4C: Biphasic control can provide mutant resistance to stem-cell homeostatic circuits.

C A mutated stem cell with a strong inactivation of the sensing of y has a growth advantage (differentiates less), and therefore, it invades the stem- cell population. As a result, both the stem-cell pool and the number of terminally differentiated cells increase.

SED-ML simulation https://jjj.bio.vu.nl/models/experiments/karin2017_fig4c/simulate

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Created: 31st Jul 2018 at 12:24

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