Frequency-dependent selection of mutant pancreatic beta cells.
SEEK ID: https://fairdomhub.org/assays/679
Modelling Analysis
Projects: Molecular Systems Biology
Investigation: Karin et al (2017) Molecular Systems Biology
Study: Figure 2: Frequency-dependent selection of mutant pancreatic beta cells.
Biological problem addressed: Model Analysis Type
Organisms: No organisms
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Created: 31st Jul 2018 at 12:31
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Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, School of Computer Science, University of Manchester, Stellenbosch University
The Molecular Systems Biology project holds information for reproducing simulation figures in the journal. This can include experimental data files, model files and manuscript information.
Programme: Journals
Public web page: http://msb.embopress.org
Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits
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Mathematical simulation of a tamoxifen-induced conditional knock-in of a sixfold activating GCK mutant in beta cells. (C) The percentage of beta cells with mutated GCK increases to ~25% after 3 days, but then decreases and is eliminated after a few weeks. (D) Glucose levels initially decrease after the tamoxifen injection, but return to normal after a few weeks. Insets: Experimental results of Tornovsky-Babeay et al (2014).
SED-ML simulation
https://jjj.bio.vu.nl/models/experiments/karin2017_fig2/simulate
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Person responsible: Jacky Snoep
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