Biphasic control can provide mutant resistance to stem-cell homeostatic circuits.
SEEK ID: https://fairdomhub.org/assays/681
Modelling Analysis
Projects: Molecular Systems Biology
Investigation: Karin et al (2017) Molecular Systems Biology
Study: Figure 4D: Biphasic control can provide mutant resistance to stem-cell homeostatic circuits.
Biological problem addressed: Model Analysis Type
Organisms: No organisms
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Created: 31st Jul 2018 at 12:32
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Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, School of Computer Science, University of Manchester, Stellenbosch University
The Molecular Systems Biology project holds information for reproducing simulation figures in the journal. This can include experimental data files, model files and manuscript information.
Programme: Journals
Public web page: http://msb.embopress.org
Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits
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D Biphasic control of stem-cell expansion, where stem-cell expansion is low both at high and low concentrations of y. The system has a stable fixed point at the concentration of y where pr = 0.5 and an unstable fixed point at some lower concentration of y.
SED-ML simulation
https://jjj.bio.vu.nl/models/experiments/karin2017_fig4d/simulate
Person responsible: Jacky Snoep
Snapshots: No snapshots
